| Size | Price | |
|---|---|---|
| 250mg | ||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Urea is readily absorbed by plant roots and transported to the leaves for accumulation… It does not easily penetrate the leaves. After administration of 175 mg/kg body weight daily for 60 consecutive days, or 0.1–20.0 mg/kg body weight daily for 6 consecutive months, the retention of urea-related substances in tissues occurred primarily in the lungs, followed by the heart, liver, brain, and kidneys, as well as milk, bone marrow, and thyroid gland. In rats orally administered 875 mg/kg body weight, peak plasma concentrations were reached 2 hours post-administration… CMPD is evenly distributed throughout the body. Metabolisms/Metabolites 3-(p-chlorophenyl)-1,1-dimethylurea is converted to 3-(p-chlorophenyl)-1-hydroxymethyl-1-methylurea in cotton; it also generates 3-(p-chlorophenyl)-1-methylurea. /Excerpt from Table/ Cotton plants degrade monoxone to monomethylmonoxone and p-chlorophenylurea via a series of demethylation reactions, followed by hydrolysis of the amide bond to p-chloroaniline. In mammals, monoxone is metabolized via three pathways: (I) oxidative demethylation; (II) aromatic nucleus hydroxylation; and (III) urea cleavage to generate chloroaniline derivatives. The yields of various metabolites indicate that hydroxylation occurs more frequently at the 2-position than the 3-position. Phenolic metabolites are excreted in urine as conjugates. 4-Chloro-2-hydroxyaniline is excreted as the N-acetyl compound 2-acetamido-5-chlorophenol. For more complete metabolite/metabolite data on MONURON (10 metabolites in total), please visit the HSDB record page. |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
In the presence of moderate concentrations of carbaryl, the degradation of mononolon in cotton plants (except for monodemethylation) is inhibited. …4-Benzothiophene-N-methylcarbamate is as effective as carbaryl. In vitro studies have shown that flavin (flavin mononucleotide) can cause photoinactivation of phenylurea drugs (such as mononolon). Non-human Toxicity Values Oral LD50 in rats: 3600 mg mononolon/kg Dietary: Rats and dogs: No effect level: 250-500 ppm |
| References | |
| Additional Infomation |
Monuron is a white crystalline solid or white powder with a slight odor. Melting point: 175℃. It is poisonous and can be ingested. It is used as a herbicide. Monuron belongs to the 3-(3,4-substituted phenyl)-1,1-dimethylurea class of compounds, in which one nitrogen atom is replaced by a p-chlorophenyl group, and the other nitrogen atom is replaced by two methyl groups. It is both a herbicide and an exogenous substance and environmental pollutant. It belongs to the monochlorobenzene class of compounds and is also a 3-(3,4-substituted phenyl)-1,1-dimethylurea class. Mechanism of Action: Substituted urea compounds…in leaves…cause the collapse of parenchyma vascular bundles. …They inhibit photosynthesis…and are potent inhibitors of water oxidation to oxygen (Hill reaction)…Studies have shown that mononucleotides block photosynthesis at the electron transfer site of flavin mononucleotides…
|
| Molecular Formula |
C9H11CLN2O
|
|---|---|
| Molecular Weight |
198.65
|
| Exact Mass |
198.055
|
| CAS # |
150-68-5
|
| Related CAS # |
Monuron-d6;217488-65-8
|
| PubChem CID |
8800
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
358.8±34.0 °C at 760 mmHg
|
| Melting Point |
173-174 °C(lit.)
|
| Flash Point |
170.8±25.7 °C
|
| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.595
|
| LogP |
1.89
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
13
|
| Complexity |
177
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BMLIZLVNXIYGCK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H11ClN2O/c1-12(2)9(13)11-8-5-3-7(10)4-6-8/h3-6H,1-2H3,(H,11,13)
|
| Chemical Name |
3-(4-chlorophenyl)-1,1-dimethylurea
|
| Synonyms |
Monuron; Monurex; Lirobetarex
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~251.70 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0340 mL | 25.1699 mL | 50.3398 mL | |
| 5 mM | 1.0068 mL | 5.0340 mL | 10.0680 mL | |
| 10 mM | 0.5034 mL | 2.5170 mL | 5.0340 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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