| Size | Price | |
|---|---|---|
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
SUBSTITUTED UREAS ARE READILY ABSORBED BY PLANT ROOTS & TRANSLOCATED TO ACCUMULATE IN LEAVES ... THEY DO NOT PENETRATE READILY THROUGH LEAVES. AFTER ADMIN OF 175 MG/KG BODY WT/DAY FOR 60 DAYS OR OF 0.1-20.0 MG/KG BODY WT FOR 6 MO, TISSUE RETENTION OF MONURON-RELATED SUBSTANCES OCCURRED /MOST/ IN LUNGS, /DECR RESPECTIVELY IN/ HEART, LIVER, BRAIN & KIDNEYS, MILK, BONE MARROW & THYROID GLAND. IN RATS GIVEN 875 MG/KG BODY WT ORALLY, PEAK BLOOD CONCN OCCURRED 2 HR AFTER DOSING ... CMPD WAS DISTRIBUTED EVENLY THROUGHOUT BODY. Metabolism / Metabolites 3-(P-CHLOROPHENYL)-1,1-DIMETHYLUREA YIELDS IN COTTON 3-(P-CHLOROPHENYL)-1-HYDROXYMETHYL-1-METHYLUREA; ALSO YIELDS 3-(P-CHLOROPHENYL)-1-METHYLUREA. /FROM TABLE/ COTTON PLANTS DEGRADED MONURON TO MONOMETHYLMONURON & P-CHLORO-PHENYLUREA BY SUCCESSIVE DEMETHYLATIONS & THEN TO P-CHLOROANILINE BY HYDROLYSIS OF AMIDE BOND. IN MAMMALS, MONURON IS METABOLIZED (I) BY OXIDATIVE N-DEMETHYLATION, (II) BY HYDROXYLATION OF AROMATIC NUCLEUS & (III) BY FISSION OF UREA RESIDUE TO GIVE CHLOROANILINE DERIVATIVES. YIELDS OF VARIOUS METABOLITES INDICATE THAT HYDROXYLATION FAVORS 2-POSITION RATHER THAN 3-POSITION. PHENOLIC METABOLITES WERE EXCRETED IN URINE AS CONJUGATES. 4-CHLORO-2-HYDROXYANILINE WAS EXCRETED AS THE N-ACETYL CMPD 2-ACETAMINO-5-CHLOROPHENOL. For more Metabolism/Metabolites (Complete) data for MONURON (10 total), please visit the HSDB record page. |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
IN PRESENCE OF MODERATE AMT OF CARBARYL, DEGRADATION /OF MONURON IN COTTON PLANTS/ BEYOND MONO-DEMETHYLATION WAS INHIBITED. ... 4-BENZOTHIOPHENE-N-METHYLCARBAMATE WAS AS EFFECTIVE AS CARBARYL. FLAVINS (FLAVINMONONUCLEOTIDE) HAVE BEEN SHOWN TO CAUSE PHOTOINACTIVATION OF PHENYLUREAS, SUCH AS MONURON, IN VITRO. Non-Human Toxicity Values LD50 Rat oral 3600 mg monuron/kg In diet: rats and dogs: no effect level: 250-500 ppm |
| References | |
| Additional Infomation |
Monuron appears as white crystalline solid or white powder with a slight odor. Melting point 175 °C. Moderately toxic by ingestion. Used as an herbicide.
Monuron is a member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which one of the nitrogens is substituted by a p-chlorophenyl group while the other is substituted by two methyl groups. It has a role as a herbicide, a xenobiotic and an environmental contaminant. It is a member of monochlorobenzenes and a 3-(3,4-substituted-phenyl)-1,1-dimethylurea. Mechanism of Action SUBSTITUTED UREAS ... IN LEAVES ... CAUSE COLLAPSE OF PARENCHYMA VESSELS. ... THEY INHIBIT PHOTOSYNTHESIS ... AND ARE POWERFUL INHIBITORS OF OXIDATION OF WATER TO OXYGEN (HILL REACTION) ... SUGGESTED THAT MONURON BLOCKS PHOTOSYNTHESIS AT SITE OF ELECTRON TRANSFER BY FLAVIN MONONUCLEOTIDE ... . |
| Molecular Formula |
C9H11CLN2O
|
|---|---|
| Molecular Weight |
198.65
|
| Exact Mass |
198.055
|
| CAS # |
150-68-5
|
| Related CAS # |
Monuron-d6;217488-65-8
|
| PubChem CID |
8800
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
358.8±34.0 °C at 760 mmHg
|
| Melting Point |
173-174 °C(lit.)
|
| Flash Point |
170.8±25.7 °C
|
| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.595
|
| LogP |
1.89
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
13
|
| Complexity |
177
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BMLIZLVNXIYGCK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H11ClN2O/c1-12(2)9(13)11-8-5-3-7(10)4-6-8/h3-6H,1-2H3,(H,11,13)
|
| Chemical Name |
3-(4-chlorophenyl)-1,1-dimethylurea
|
| Synonyms |
Monuron; Monurex; Lirobetarex
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~251.70 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0340 mL | 25.1699 mL | 50.3398 mL | |
| 5 mM | 1.0068 mL | 5.0340 mL | 10.0680 mL | |
| 10 mM | 0.5034 mL | 2.5170 mL | 5.0340 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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