| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
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| ln Vitro |
Fusarium moniliforme NRRL 6322 produces approximately 600 mg of recoverable moniliformin (a mold toxic metabolite) per kilogram of maize residue growth media. Some strains of Fusarium moniliforme can produce more than 800 mg of moniliformin per kilogram of growth medium in experimental cultures [1]. After monocyte-derived macrophages are exposed to streptozotocin throughout the differentiation process, their endocytic capacity declines, and the expression of CD71 and HLA-DR decreases [2].
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|---|---|
| ln Vivo |
Bephiformin had a lower lethal dose (LD50) in mice, ranging from 20.9 mg/kg for female mice to 29.1 mg/kg for male mice. The mice who withstood the poison showed no negative consequences, as did the chicks. Following therapy, dead mice or chicks return to a recumbent position in 4–6 hours and pass away in 24 hours. There is no evident teratogenic effect on surviving in 4-day-old chicken embryos, with an LD50 of up to 2.8 μg per embryo [1]. After receiving the maximum dosage of bephiformin, the rats' activity levels decreased, and they eventually died of severe heart failure. Lower doses (<9 mg/kg bw) did not cause any harm in rats. All dose groups' neutrophil phagocytic activity was significantly decreased by daily streptozolin consumption. With a LOAEL value of 3 mg/kg bw for biformin, the satellite group's drop during the follow-up period indicated serious immune system consequences. Beliformin is readily eliminated in the urine, with no signs of buildup, ranging from 20.2% to 31.5% of daily excretion. Less than 2% of befomin is found in feces, which suggests effective absorption from the gastrointestinal tract [3].
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| References |
|
| Additional Infomation |
See also: Moniliformin (annotation moved to).
|
| Molecular Formula |
C4HO3-.NA+
|
|---|---|
| Molecular Weight |
120.03874
|
| Exact Mass |
119.982
|
| CAS # |
71376-34-6
|
| Related CAS # |
31876-38-7 (Parent)
|
| PubChem CID |
23691721
|
| Appearance |
Light yellow to yellow solid powder
|
| Boiling Point |
239.6ºC at 760 mmHg
|
| Flash Point |
113ºC
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
|
| Heavy Atom Count |
8
|
| Complexity |
170
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
FERDNJVXTWPNSA-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
|
| Chemical Name |
sodium;3,4-dioxocyclobuten-1-olate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~833.06 mM)
DMSO : ≥ 45 mg/mL (~374.88 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (277.66 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.3306 mL | 41.6528 mL | 83.3056 mL | |
| 5 mM | 1.6661 mL | 8.3306 mL | 16.6611 mL | |
| 10 mM | 0.8331 mL | 4.1653 mL | 8.3306 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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