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    ML324 (CID44143209)
    ML324 (CID44143209)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0375
    CAS #: 1222800-79-4Purity ≥98%

    Description: ML324 (also known as CID-44143209) is a cell-permeable and selective inhibitor of jumonji histone demethylase (JMJD2) with antiviral activity. It inhibits JMJD2 demethylase with an IC50 of 920 nM. ML324 exhibits potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. 

    References: Probe Reports from the NIH Molecular Libraries Program; Neuropsychopharmacology. 2016 Oct 26. doi: 10.1038/npp.2016.231. 

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    Molecular Weight (MW)349.43
    FormulaC21H23N3O2
    CAS No.1222800-79-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 43 mg/mL (123.0 mM)
    Water:<1 mg/mL
    Ethanol: 3 mg/mL (8.6 mM) 
    SMILESO=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1
    Synonyms

    CID 44143209; CID-44143209; CID44143209; ML 324; ML-324; ML324

    Chemical Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide

    InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

    SMILES Code: O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1 


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    In Vitro

    In vitro activity: ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.


    Kinase Assay: ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). 


    Cell Assay: ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread.

    In VivoIn a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation
    Animal modelMice
    Formulation & DosageN/A
    References

    Probe Reports from the NIH Molecular Libraries Program;


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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