| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
In human plasma, mequelianin demonstrates antioxidant properties. The consumption of three antioxidants, lycopene, β-carotene, and α-tocopherol, is considerably inhibited by miquelianin at 50 μM [1]. Miquelianin can go from the small intestine to the central nervous system, according to in vitro research [2]. Miquelianin dramatically lowers the synthesis of beta-amyloid (Aβ) peptides in primary neuronal cells derived from the AD animal model Tg2576. Additionally, it possesses the ability to disrupt the preliminary protein-protein interaction between Aβ1-40 and Aβ1-42, which is necessary for the development of neurotoxic oligomeric Aβ species [3]. ROS production, cAMP and RAS activation, ERK1/2 phosphorylation, and the expression of the HMOX1, MMP2, and MMP9 genes were all reduced by treatment with 0.1 μM miquelianin. Miquelianin prevents [3H]-NA from binding to b2-AR and prevents MDA-MB-231 breast cancer cells from invading and inducing MMP-9. Miquelianin may be a dietary chemopreventive factor in stress-related breast cancer and may decrease breast cancer cell invasion by regulating b2-adrenergic signaling [4].
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| ln Vivo |
When compared to vehicle control treatment, meiquelianin administration dramatically repaired AD-type impairments in basal synaptic transmission and long-term potentiation in the hippocampus formation [3].
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| References |
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| Additional Infomation |
Miquelianin is a quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities. It has a role as a metabolite, an antioxidant and an antidepressant. It is a beta-D-glucosiduronic acid and a quercetin O-glycoside.
quercetin 3-O-glucuronide has been reported in Callistemon citrinus, Myrothamnus flabellifolia, and other organisms with data available. See also: Bilberry (part of); Theobroma grandiflorum seed (part of). |
| Molecular Formula |
C21H18O13
|
|---|---|
| Molecular Weight |
478.362
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| Exact Mass |
478.074
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| CAS # |
22688-79-5
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| PubChem CID |
5274585
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| Appearance |
Light yellow to yellow solid powder
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| Density |
2.0±0.1 g/cm3
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| Boiling Point |
927.8±65.0 °C at 760 mmHg
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| Flash Point |
325.8±27.8 °C
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| Vapour Pressure |
0.0±0.3 mmHg at 25°C
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| Index of Refraction |
1.819
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| LogP |
2.1
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| Hydrogen Bond Donor Count |
8
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
34
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| Complexity |
830
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| Defined Atom Stereocenter Count |
5
|
| SMILES |
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O
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| InChi Key |
DUBCCGAQYVUYEU-ZUGPOPFOSA-N
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| InChi Code |
InChI=1S/C21H18O13/c22-7-4-10(25)12-11(5-7)32-17(6-1-2-8(23)9(24)3-6)18(13(12)26)33-21-16(29)14(27)15(28)19(34-21)20(30)31/h1-5,14-16,19,21-25,27-29H,(H,30,31)/t14-,15-,16+,19-,21+/m0/s1
|
| Chemical Name |
(2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
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| Synonyms |
Quercituron Mikwelianin Miquelianin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 30 mg/mL (~62.71 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0905 mL | 10.4524 mL | 20.9048 mL | |
| 5 mM | 0.4181 mL | 2.0905 mL | 4.1810 mL | |
| 10 mM | 0.2090 mL | 1.0452 mL | 2.0905 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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