| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| References |
|
|---|---|
| Additional Infomation |
Milrinone lactate is the lactate form of milrinone, a cardiovascular bipyridine drug and phosphodiesterase (PDE) III inhibitor with positive inotropic and vasodilatory effects. After administration, milrinone selectively inhibits PDE-mediated cyclic adenosine monophosphate (cAMP) degradation in myocardial and vascular smooth muscle, thereby increasing cAMP levels and activating protein kinase A (PKA). This leads to calcium ion channel phosphorylation and enhances myocardial contractility. Milrinone also dilates the smooth muscle of arterioles and venules.
A positive inotropic drug with vasodilatory effects. It inhibits cAMP phosphodiesterase type III activity in myocardial and vascular smooth muscle. Milrinone is a derivative of amrinone, and its positive inotropic effect is 20-30 times stronger than that of amrinone. See also: Milrinone (with active fraction). |
| Molecular Formula |
C15H15N3O4
|
|---|---|
| Molecular Weight |
301.302
|
| Exact Mass |
301.106
|
| CAS # |
100286-97-3
|
| Related CAS # |
Milrinone;78415-72-2
|
| PubChem CID |
172293
|
| Appearance |
Off-white to light brown solid
|
| Boiling Point |
448.7ºC at 760 mmHg
|
| Flash Point |
225.2ºC
|
| Vapour Pressure |
3.04E-08mmHg at 25°C
|
| LogP |
1.068
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
22
|
| Complexity |
478
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
N#CC1=CC(C2=CC=NC=C2)=C(C)NC1=O.CC(O)C(O)=O
|
| InChi Key |
VWUPWEAFIOQCGF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-81-2(4)3(5)6/h2-6H,1H3,(H,15,16)2,4H,1H3,(H,5,6)
|
| Chemical Name |
6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile Lactate
|
| Synonyms |
Milrinone Lactate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~100 mg/mL (with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3190 mL | 16.5948 mL | 33.1895 mL | |
| 5 mM | 0.6638 mL | 3.3190 mL | 6.6379 mL | |
| 10 mM | 0.3319 mL | 1.6595 mL | 3.3190 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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