| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| References |
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| Additional Infomation |
Pantothenic acid is a monocarboxylic acid used as a radioactive contrast agent. Pantothenic acid is a molecule used as a contrast agent. Due to its high osmotic pressure, it carries a high risk of allergic reactions. The U.S. Food and Drug Administration (FDA) has discontinued its approval for use. A 1976 study showed that pantothenic acid was well tolerated for use in cardiac angiography. Over a three-year period, 2028 patients undergoing cardiovascular angiography received 10,000 injections. With two exceptions, all complications occurred during injections into the right coronary artery. Seven cases of ventricular fibrillation and five cases of significant bradycardia/cardiac arrest were associated with pantothenic acid injections. Overall, patients tolerated the drug well during cardiac examinations. Pantothenic acid is a radioactive contrast agent. The mechanism of action of pantothenic acid is as an X-ray contrast agent. A diagnostic radiopaque agent, usually present in sodium salt form. See also: ... See more ...
Drug Indications Used as a contrast agent. Mechanism of Action The mechanism of action of mecofluidic acid is as an X-ray contrast agent. |
| Molecular Formula |
C12H11I3N2O4
|
|---|---|
| Molecular Weight |
627.94
|
| Exact Mass |
627.785
|
| CAS # |
1949-45-7
|
| PubChem CID |
2528
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
2.483g/cm3
|
| Boiling Point |
678.8ºC at 760mmHg
|
| Flash Point |
364.3ºC
|
| Vapour Pressure |
2.35E-19mmHg at 25°C
|
| Index of Refraction |
1.77
|
| LogP |
3.212
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
21
|
| Complexity |
448
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
IC1=C(C(=C(C(=O)O[H])C(=C1N(C(C([H])([H])[H])=O)C([H])([H])[H])I)I)N([H])C(C([H])([H])[H])=O
|
| InChi Key |
GGGDNPWHMNJRFN-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H11I3N2O4/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19/h1-3H3,(H,16,18)(H,20,21)
|
| Chemical Name |
3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid
|
| Synonyms |
Metrizoate; Metrizoic Acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~31.25 mg/mL (~49.77 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (3.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (3.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5925 mL | 7.9625 mL | 15.9251 mL | |
| 5 mM | 0.3185 mL | 1.5925 mL | 3.1850 mL | |
| 10 mM | 0.1593 mL | 0.7963 mL | 1.5925 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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