| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Methyl stearate does not have a specific pharmacological target, as it is primarily a fatty acid ester used as an emulsifier, surfactant, and cosmetic ingredient. As a fatty acid ester, it may interact with lipid membranes and act as a penetration enhancer or emollient. Methyl stearate is used as a nonionic surfactant, enhancing the solubility of chemicals by dissociating aggregates and unfolding proteins. It has a role as a metabolite and is reported in various organisms including Humulus lupulus and Ostrinia nubilalis. Its chemical properties make it useful in various industrial and research applications, including as an emulsifier and stabilizer in cosmetic and pharmaceutical formulations.
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| ln Vitro |
Methyl stearate is primarily a chemical reagent and cosmetic ingredient rather than a drug with specific in vitro pharmacological activity. It is used as a nonionic surfactant, enhancing the solubility of chemicals by dissociating aggregates and unfolding proteins. The compound's emollient and moisturizing properties make it useful in skincare products, lotions, and creams. In research settings, methyl stearate may be used as a reference standard or as a component of lipid-based formulations. Its in vitro activity is primarily related to its physicochemical properties rather than specific biological effects. The compound is widely used in the cosmetic and personal care industry.
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| ln Vivo |
In vivo, methyl stearate is not used as a therapeutic agent. However, as a fatty acid ester, it is metabolized in the body by esterases to stearic acid and methanol. Stearic acid is a common dietary fatty acid that is used for energy production or incorporated into cellular lipids. Methyl stearate is reported as a metabolite in various organisms. The compound is generally recognized as safe for use in cosmetic and personal care products. Its emollient and moisturizing properties make it suitable for topical applications.
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| Enzyme Assay |
In vitro enzyme/receptor binding (non-cellular) assays are not applicable to methyl stearate, as it is a fatty acid ester and surfactant rather than a bioactive compound with specific enzyme or receptor targets. However, the compound may be used in biochemical assays as a surfactant to solubilize hydrophobic compounds or to stabilize protein solutions. Its ability to dissociate aggregates and unfold proteins makes it useful in protein chemistry and formulation studies. The compound's surfactant properties can be characterized using surface tension, critical micelle concentration (CMC), or emulsification assays.
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| Cell Assay |
In vitro cellular experiments with methyl stearate are not typically performed for pharmacological evaluation, as the compound is primarily a cosmetic ingredient and surfactant. However, cellular assays may be conducted to assess its effects on cell membranes, lipid metabolism, or cytotoxicity. Cell lines such as keratinocytes or fibroblasts may be treated with varying concentrations of methyl stearate, and cell viability, membrane integrity, or lipid accumulation may be assessed. The compound's effects on protein solubility or aggregation in cellular contexts may also be studied. These experiments help characterize the compound's safety and potential biological effects.
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| Animal Protocol |
In vivo animal studies with methyl stearate are not typically performed for therapeutic development. However, toxicological studies may be conducted to assess the compound's safety for use in cosmetic and personal care products. Rodents or other animals are administered methyl stearate via oral, dermal, or inhalation routes at various doses. Parameters assessed include body weight, organ weights, histopathological examination, and clinical signs of toxicity. The compound is generally recognized as safe for topical use.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of methyl stearate are not extensively characterized for therapeutic applications, as the compound is primarily a cosmetic ingredient and surfactant. The compound has molecular formula C₁₉H₃₈O₂ and molecular weight 298.49. It appears as a white, odorless solid or waxy substance at room temperature. When ingested, methyl stearate is hydrolyzed by esterases to stearic acid and methanol. Stearic acid is absorbed and metabolized through fatty acid oxidation pathways. When applied topically, the compound remains primarily on the skin surface, providing emollient and moisturizing effects. Storage: follow manufacturer's guidelines.
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| Toxicity/Toxicokinetics |
Toxicological information for methyl stearate indicates that the compound is generally recognized as safe for use in cosmetic and personal care products. It appears as a white, odorless solid or waxy substance at room temperature. As a fatty acid ester, it is not expected to be toxic at typical usage levels. Standard safety precautions for handling chemicals apply, including use of personal protective equipment (gloves, safety goggles, lab coat) and working in a well-ventilated area. The compound is for research use only and is not approved for clinical use.
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| References | |
| Additional Infomation |
Methyl stearate is a white crystalline or lumpy solid. (NTP, 1992)
Methyl stearate is a fatty acid methyl ester and octadecanoate. It is a metabolic product. Methyl stearate has been reported to be found in hops (Humulus lupulus), the European corn borer (Ostrinia nubilalis), and several other organisms with relevant data. Methyl stearate (CAS 112-61-8) is a fatty acid methyl ester and an octadecanoate ester with molecular formula C₁₉H₃₈O₂ and molecular weight 298.49. It appears as a white, odorless solid or waxy substance at room temperature. Methyl stearate is a naturally occurring compound reported in Humulus lupulus, Ostrinia nubilalis, and other organisms, and has a role as a metabolite. It is used as a nonionic surfactant, emulsifier, and stabilizer, enhancing the solubility of chemicals by dissociating aggregates and unfolding proteins. Methyl stearate is widely used in the cosmetic and personal care industry as an ingredient in skincare products, lotions, and creams due to its emollient and moisturizing properties. Purity is typically ≥95%. |
| Molecular Formula |
C19H38O2
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|---|---|
| Molecular Weight |
298.5038
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| Exact Mass |
298.287
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| CAS # |
112-61-8
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| Related CAS # |
Methyl stearate-d35;29823-25-4
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| PubChem CID |
8201
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| Appearance |
White to off-white solid powder
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
181-182 ºC (4 mmHg)
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| Melting Point |
37-41 °C(lit.)
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| Flash Point |
110 ºC
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.444
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| LogP |
8.68
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
17
|
| Heavy Atom Count |
21
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| Complexity |
214
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
HPEUJPJOZXNMSJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C19H38O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21-2/h3-18H2,1-2H3
|
| Chemical Name |
methyl octadecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~41.88 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (4.19 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (4.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (4.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3501 mL | 16.7504 mL | 33.5008 mL | |
| 5 mM | 0.6700 mL | 3.3501 mL | 6.7002 mL | |
| 10 mM | 0.3350 mL | 1.6750 mL | 3.3501 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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