| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| 2g |
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| 5g |
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| Other Sizes |
| Targets |
Not applicable - this compound is primarily used as a chemical standard and fatty acid ester rather than as a drug with specific biological targets.
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|---|---|
| ln Vitro |
In vitro studies on methyl nonadecanoate are limited, as the compound is primarily used as an analytical standard and chemical intermediate rather than as a bioactive compound with specific pharmacological targets. The compound is a saturated fatty acid methyl ester that may be used as a reference material in lipidomics and metabolomics studies. As a fatty acid ester, it may be hydrolyzed to nonadecanoic acid, a long-chain saturated fatty acid that can be incorporated into cellular membranes and used as an energy source. However, the biological activities of methyl nonadecanoate itself are not well characterized, and it is not typically studied for specific pharmacological effects.
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| ln Vivo |
In vivo studies on methyl nonadecanoate are limited, as the compound is not typically used as a therapeutic agent. It may be used in nutritional studies as a component of diets or dietary supplements containing nonadecanoate, where it serves as a source of the fatty acid nonadecanoic acid. Nonadecanoic acid, the free acid form, has been studied for its potential effects on metabolism and health, but methyl nonadecanoate itself is primarily used as a chemical intermediate and analytical standard rather than for in vivo pharmacological studies.
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| Enzyme Assay |
For analytical chemistry applications, methyl nonadecanoate is used as a standard for gas chromatography (GC) or gas chromatography-mass spectrometry (GC-MS) analysis of fatty acid methyl esters. The compound is injected onto a GC column, and its retention time and mass spectrum are used to identify and quantify fatty acid methyl esters in complex mixtures. For enzymatic hydrolysis studies, lipase or esterase assays may be performed to measure the hydrolysis of methyl nonadecanoate to nonadecanoic acid and methanol. The reaction is monitored by GC or HPLC to measure the disappearance of the substrate and appearance of products.
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| Cell Assay |
Cellular assays for methyl nonadecanoate are not commonly performed, as the compound is not typically studied for pharmacological activity. In lipidomics studies, cells may be treated with the compound or its metabolites to study fatty acid uptake, incorporation into cellular lipids, and effects on lipid metabolism. Fatty acid uptake is measured using radiolabeled or fluorescently labeled fatty acids, and lipid composition is analyzed by LC-MS or GC-MS. Cytotoxicity against mammalian cells may be assessed in parallel if the compound is being evaluated as a potential therapeutic agent, though this is not a primary application.
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| Animal Protocol |
In vivo studies on methyl nonadecanoate are not commonly performed for pharmacological evaluation. The compound may be used in nutritional studies as a component of diets or dietary supplements to study the effects of nonadecanoate on metabolism. In such studies, animals are fed diets containing methyl nonadecanoate or nonadecanoic acid, and parameters such as body weight, food intake, serum lipid profiles, and tissue fatty acid composition are measured. The compound's metabolic fate, including hydrolysis to nonadecanoic acid and incorporation into lipids, may be studied using stable isotope-labeled versions of the compound.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of methyl nonadecanoate have been characterized in the context of its use as a dietary fatty acid ester. Following ingestion, the compound is likely hydrolyzed by lipases in the gastrointestinal tract to release nonadecanoic acid and methanol. Nonadecanoic acid is absorbed and incorporated into chylomicrons for transport in the circulation. The compound's high molecular weight (312.53) and lipophilic nature influence its absorption, distribution, metabolism, and excretion characteristics. Nonadecanoic acid is metabolized through β-oxidation in mitochondria and peroxisomes, and may be incorporated into cellular membranes or used as an energy source.
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| Toxicity/Toxicokinetics |
Toxicological evaluation of methyl nonadecanoate indicates that it is generally considered safe for use as a food ingredient and dietary supplement component at appropriate levels. As a fatty acid ester, it is metabolized to nonadecanoic acid, a naturally occurring saturated fatty acid, and methanol, which is metabolized to formaldehyde and formic acid. Standard toxicology assessments include acute and repeated-dose toxicity studies, genotoxicity assays, and evaluation of effects on lipid metabolism and liver function. The compound's safety profile is established for food and dietary supplement applications, though comprehensive toxicology data for pharmaceutical applications may be limited.
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| References | |
| Additional Infomation |
Methyl nonadecanoate is a fatty acid methyl ester formed by the condensation of the carboxyl group of nonadecanoic acid with methanol. Functionally, it is related to nonadecanoic acid.
Methyl nonadecanoate is a fatty acid methyl ester used primarily as an analytical standard for GC and GC-MS analysis of fatty acids, as a chemical intermediate in organic synthesis, and as a component of diets and dietary supplements containing nonadecanoate. The compound is not a drug and is not intended for therapeutic use. Its primary applications are in analytical chemistry, food science, and lipid research. Nonadecanoic acid, the free acid form, has been studied for its potential effects on metabolism and health, and methyl nonadecanoate serves as a convenient esterified form for use in dietary studies and as an analytical standard. The compound is generally recognized as safe for food and research applications. |
| Molecular Formula |
C20H40O2
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|---|---|
| Molecular Weight |
312.5304
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| Exact Mass |
312.302
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| CAS # |
1731-94-8
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| PubChem CID |
15610
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| Appearance |
White to off-white solid powder
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
362.8±5.0 °C at 760 mmHg
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| Melting Point |
37-40 °C(lit.)
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| Flash Point |
176.9±7.5 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.446
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| LogP |
9.21
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
18
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| Heavy Atom Count |
22
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| Complexity |
226
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BDXAHSJUDUZLDU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H40O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-2/h3-19H2,1-2H3
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| Chemical Name |
methyl nonadecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~32.00 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (3.20 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 1 mg/mL (3.20 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1 mg/mL (3.20 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1997 mL | 15.9985 mL | 31.9969 mL | |
| 5 mM | 0.6399 mL | 3.1997 mL | 6.3994 mL | |
| 10 mM | 0.3200 mL | 1.5998 mL | 3.1997 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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