| Size | Price | Stock | Qty |
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| 10g |
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| Other Sizes |
| Targets |
Methyl 2-furoate targets inflammatory pathways. It has been shown to have anti-inflammatory properties through its inhibitory effect on prostaglandin synthesis. The compound demonstrates anti-inflammatory capabilities that hold promise for the management of conditions like arthritis and colitis. It is a building block used in chemical synthesis and in the preparation of sesquiterpene lactones.
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| ln Vitro |
In vitro, Methyl 2-furoate has been shown to have anti-inflammatory properties through its inhibitory effect on prostaglandin synthesis. It is a building block in chemical synthesis. The compound can be used to synthesize cis-fused 5-oxofuro[2,3-b]furans and is used in the preparation of sesquiterpene lactones. It is a flavoring agent found in various fruits and foods.
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| ln Vivo |
In vivo, Methyl 2-furoate has shown potential for the management of inflammatory conditions such as arthritis and colitis. As an anti-inflammatory agent, it may have therapeutic applications. The compound is found in various foods including cranberries, guava fruits, raisins, baked potato, roasted hazelnuts, peanuts, tomatoes, coffee, cocoa, and okra. Further in vivo studies are needed to fully characterize its therapeutic potential.
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| Enzyme Assay |
In vitro enzyme assays for Methyl 2-furoate involve measuring its anti-inflammatory activity through inhibition of prostaglandin synthesis. Prostaglandin synthesis is assessed by measuring prostaglandin levels using ELISA or other detection methods. The compound is added at varying concentrations, and IC50 values are calculated from dose-response curves. For synthesis studies, the compound is used as a building block in chemical reactions. Assays are performed in appropriate buffer systems with positive controls such as known anti-inflammatory agents.
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| Cell Assay |
In vitro cell-based assays for Methyl 2-furoate are conducted in inflammatory cell models. Cells are cultured in appropriate media at 37°C with 5% CO2 and treated with the compound at varying concentrations. Anti-inflammatory activity is assessed by measuring prostaglandin and cytokine production. Cell viability is assessed by standard assays. Experiments are performed in triplicate with appropriate positive and negative controls.
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| Animal Protocol |
Methyl 2-furoate in vivo studies are conducted in animal models of inflammation such as arthritis and colitis. Animals are treated with the compound via oral administration or injection. Inflammatory markers and disease progression are monitored. Animals are monitored for clinical signs. Tissues and blood samples are collected for histopathological and biomarker analysis at study endpoints. Studies are conducted in accordance with institutional animal care guidelines.
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| ADME/Pharmacokinetics |
Methyl 2-furoate (MW 126.11 g/mol, C6H6O3) is a building block in chemical synthesis. It is found in cocoa and cocoa products. The compound is soluble in organic solvents. It is stable under recommended storage conditions. Methyl 2-furoate is a flavoring agent used in food applications. Pharmacokinetic parameters such as half-life, bioavailability, and tissue distribution would be determined in species-specific studies.
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| Toxicity/Toxicokinetics |
Methyl 2-furoate is generally recognized as safe as a flavoring agent found in various foods. Its anti-inflammatory properties have been demonstrated with acceptable safety profiles. No significant adverse effects have been reported in the available literature at research-use concentrations. The compound is intended for research use only. Standard safety precautions should be followed when handling. Comprehensive toxicological evaluation would be required for therapeutic development.
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| Additional Infomation |
Methyl 2-furanoate is a carboxylic acid ester whose function is related to 2-furanoic acid. It has been reported that methyl 2-furanoate is found in Chinese kiwifruit, papaya, and mango, and relevant data are available for reference.
Methyl 2-furoate (Methyl furan-2-carboxylate) is a building block in chemical synthesis and a flavoring agent found in cranberries, guava fruits, raisins, and other foods. It exhibits anti-inflammatory properties through inhibition of prostaglandin synthesis. The compound shows promise for the management of inflammatory conditions such as arthritis and colitis. Its molecular formula is C6H6O3 with a molecular weight of 126.11 g/mol. All applications are limited to non-human research use. |
| Molecular Formula |
C6H6O3
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|---|---|
| Molecular Weight |
126.1100
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| Exact Mass |
126.031
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| CAS # |
611-13-2
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| PubChem CID |
11902
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| Appearance |
Light yellow to yellow liquid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
181.3±0.0 °C at 760 mmHg
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| Melting Point |
36ºC
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| Flash Point |
73.3±0.0 °C
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| Vapour Pressure |
0.9±0.3 mmHg at 25°C
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| Index of Refraction |
1.463
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| LogP |
0.99
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
9
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| Complexity |
111
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H]
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| InChi Key |
HDJLSECJEQSPKW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H6O3/c1-8-6(7)5-3-2-4-9-5/h2-4H,1H3
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| Chemical Name |
methyl furan-2-carboxylate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1982.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (16.49 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (16.49 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (16.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9296 mL | 39.6479 mL | 79.2959 mL | |
| 5 mM | 1.5859 mL | 7.9296 mL | 15.8592 mL | |
| 10 mM | 0.7930 mL | 3.9648 mL | 7.9296 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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