| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
Drugs are released from hypromellose in a regulated manner, which effectively lengthens the time the medication is released and its therapeutic effect [1]. Pharmaceuticals with prolonged release have long included hydroxypropyl methylcellulose, or hypromellose. These polymers are employed in matrix tablets, and when they come into touch with water, they hydrate and form a viscous gel barrier inside and around the tablet. The rate of water diffusion into the dry polymer, the rate of hydration and gel formation, the viscosity of hydrated hypromellose, and the rate of coagulation of hypromellose are among the hypromellose properties that influence drug release rates. Rate of glue erosion [2].
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| ln Vivo |
For dry eye syndrome, puncttal sealing with 2% hypromellose is an inexpensive and secure adjunctive treatment. Following hypromellose occlusion, there was a noticeable decrease in symptoms according to studies using fluorescein and rose bengal staining [3]. In mice given a high-fat diet, hypromellose can successfully enhance blood glucose metabolism and reduce oxidative stress. The modification of hepatic glucose-regulating enzyme activity and the activation of hepatic and erythrocyte antioxidant enzymes are partially responsible for the antihyperglycemic and antioxidant actions of hypromellose. Hypromellose can be employed as a biomaterial in the production of functional foods or as a medication to treat oxidative stress and hyperglycemia brought on by a high fat diet [4].
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| References |
[1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46.
[2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing. [3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92. [4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50. |
| Molecular Formula |
C36H70O19.C20H38O11
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|---|---|
| Molecular Weight |
1261.43872
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| CAS # |
9004-65-3
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| Related CAS # |
HPMC (Type II,Viscosity:5mPa.s);9004-65-3
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| SMILES |
OC[C@H]1O[C@@H](O[C@H]2C(O)[C@@H](O)[C@H](OC)O[C@@H]2CO)[C@H](O)C(O)[C@@H]1OC.CO.CC(O)CO.[n]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL
H2O : ~10 mg/mL |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.7927 mL | 3.9637 mL | 7.9274 mL | |
| 5 mM | 0.1585 mL | 0.7927 mL | 1.5855 mL | |
| 10 mM | 0.0793 mL | 0.3964 mL | 0.7927 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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