| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| ln Vitro |
Formaldehyde is released by the urinary antibacterial agent hexamine hippurate, which is eliminated in the urine. At pH 5 to 6, urotropine hippurate exhibits strong in vitro action against Escherichia coli, Staphylococcus aureus, Aerobacter, Pseudomonas aeruginosa, and Proteus vulgaris. It also exhibits activity against Klebsiella pneumoniae. The consequences of Lebsiella and Proteus species are diverse. Staphylococcus aureus, Escherichia coli, and pseudomonas aeruginosa. Hemolytic Streptococcus and Staphylococcus aureus at pH 7.4. Compared to methenamine, hippuric acid, or sulfadiazine alone, this impact is more potent [1].
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| Toxicity/Toxicokinetics |
Effects During Pregnancy and Lactation
◉ Overview of Use During Lactation Methylamine can pass into breast milk in small amounts, and its use appears to be safe even during the nursing period for newborns. ◉ Effects on Breastfed Infants In one study, four newborns were allowed to breastfeed after their mothers took 1 gram of hippuric methylamine. No adverse reactions were reported. ◉ Effects on Lactation and Breast Milk As of the revision date, no relevant published information was found. |
| References |
[1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 20
[2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170. |
| Additional Infomation |
Methylhamine hippurate is an N-acylglycine that functions similarly to N-benzoylglycine. It is the hippurate salt form of methylamine, a prodrug and an inactive weak base that slowly hydrolyzes in acidic urine to ammonia and formaldehyde, a potent urinary tract disinfectant. Formaldehyde may exert its antibacterial effect through protein denaturation. Depending on the urine concentration, formaldehyde can exhibit bactericidal or bacteriostatic activity. The concentration of formaldehyde in urine depends on the pH, volume, and flow rate. Formaldehyde is antibacterial against both Gram-positive and Gram-negative bacteria. See also: Methylamine (containing the active moiety).
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| Molecular Formula |
C₁₅H₂₁N₅O₃
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|---|---|
| Molecular Weight |
319.36
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| Exact Mass |
319.164
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| CAS # |
5714-73-8
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| PubChem CID |
21945
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| Appearance |
Typically exists as solid at room temperature
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| Boiling Point |
464.1ºC at 760mmHg
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| Melting Point |
89-95ºC
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| Flash Point |
234.5ºC
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
23
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| Complexity |
282
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([H])([H])C(=O)O[H].N12C([H])([H])N3C([H])([H])N(C([H])([H])N(C3([H])[H])C1([H])[H])C2([H])[H]
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| Synonyms |
Methenamine hippurate; Methenamine hippurate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~313.13 mM)
DMSO : ~25 mg/mL (~78.28 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (313.13 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1313 mL | 15.6563 mL | 31.3126 mL | |
| 5 mM | 0.6263 mL | 3.1313 mL | 6.2625 mL | |
| 10 mM | 0.3131 mL | 1.5656 mL | 3.1313 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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