| Size | Price | |
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| Other Sizes |
| Targets |
Methacrylic anhydride does not have a specific biological target. As a reactive chemical intermediate, it is not a pharmacologically active agent. Its mechanism of action is chemical rather than biological. Methacrylic anhydride reacts with nucleophilic groups such as hydroxyl, amino, and thiol groups, forming ester, amide, and thioester derivatives. This reactivity is exploited in organic synthesis for the introduction of methacryloyl groups into molecules. In biological contexts, methacrylic anhydride may react non-specifically with proteins and other biomolecules, but this is not a pharmacological effect.
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| ln Vitro |
Methacrylic anhydride is not a pharmacological agent and does not have in vitro biological activity. Its utility is as a chemical reagent and synthetic intermediate. The compound is used in polymer chemistry for the preparation of methacrylate polymers and copolymers. It is also used as a reagent for the methacryloylation of hydroxyl-containing compounds, including sugars, alcohols, and other functionalized molecules. In research applications, methacrylic anhydride is used to modify biomolecules for the preparation of hydrogels and other biomaterials.
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| ln Vivo |
Methacrylic anhydride is not a therapeutic agent and does not have in vivo pharmacological activity. It is not administered to animals for therapeutic or pharmacological studies. Its use is limited to chemical synthesis and as a research reagent. The compound is not intended for human consumption or therapeutic use.
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| Enzyme Assay |
Methacrylic anhydride is not used in non-cellular enzyme/receptor binding assays. Its application is limited to chemical synthesis and polymer chemistry. The compound's reactivity can be assessed using standard organic chemistry methods such as NMR spectroscopy, mass spectrometry, and chromatographic techniques to monitor reaction progress and product formation in synthetic transformations.
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| Cell Assay |
Methacrylic anhydride is not used in in vitro cellular assays for pharmacological evaluation. The compound is a reactive chemical that may cause cellular toxicity due to its reactivity with cellular proteins and other biomolecules. It is not used as a biological tool or pharmacological agent. Any cellular effects would be due to non-specific chemical reactivity rather than specific biological activity.
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| Animal Protocol |
Methacrylic anhydride is not used in in vivo animal studies as a therapeutic or pharmacological agent. Its use is limited to chemical synthesis and research applications as a synthetic intermediate. The compound is not administered to animals for therapeutic or pharmacological studies.
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| ADME/Pharmacokinetics |
Methacrylic anhydride is not a drug and does not have pharmacokinetic properties. Its physical and chemical properties are more relevant: it is a clear, colorless to pale yellow liquid with a molecular weight of 154.16 and a molecular formula of C₈H₁₀O₃. The compound is soluble in organic solvents and reacts with water (hydrolysis). It should be stored under anhydrous conditions and protected from moisture.
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| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Mouse) = 450 mg/m³/2h Non-human Toxicity Values LC50 (Mouse) ihl 450 mg/m³/2h Methacrylic anhydride is a corrosive and irritating compound. It is toxic if swallowed, inhaled, or absorbed through the skin. The compound causes severe skin burns and eye damage. Inhalation may cause respiratory irritation and damage. Prolonged or repeated exposure may cause sensitization. Methacrylic anhydride is also flammable and should be handled away from heat and open flames. Appropriate personal protective equipment (gloves, goggles, protective clothing) should be worn when handling this compound. Work should be conducted in a well-ventilated area or in a fume hood. |
| References | |
| Additional Infomation |
Methacrylic anhydride is a liquid. (EPA, 1998)
Methacrylic anhydride is a research-grade chemical reagent intended for laboratory use only and is not approved for clinical use. Its CAS number is 760-93-0. The primary applications of methacrylic anhydride include use as a monomer for the production of polymers and copolymers, as a reagent for the introduction of methacryloyl groups into various molecules, and as a synthetic intermediate in organic synthesis. The compound is also used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Methacrylic anhydride is a valuable tool for polymer chemistry and materials science research. |
| Molecular Formula |
C8H10O3
|
|---|---|
| Molecular Weight |
154.1632
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| Exact Mass |
154.062
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| CAS # |
760-93-0
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| Related CAS # |
25300-99-6
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| PubChem CID |
12974
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
202.3±0.0 °C at 760 mmHg
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| Melting Point |
-20°C
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| Flash Point |
84.4±0.0 °C
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| Vapour Pressure |
0.3±0.4 mmHg at 25°C
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| Index of Refraction |
1.443
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| LogP |
1.82
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
11
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| Complexity |
202
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C(C(=C([H])[H])C([H])([H])[H])=O)C(C(=C([H])[H])C([H])([H])[H])=O
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| InChi Key |
DCUFMVPCXCSVNP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H10O3/c1-5(2)7(9)11-8(10)6(3)4/h1,3H2,2,4H3
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| Chemical Name |
2-methylprop-2-enoyl 2-methylprop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~648.63 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4868 mL | 32.4338 mL | 64.8677 mL | |
| 5 mM | 1.2974 mL | 6.4868 mL | 12.9735 mL | |
| 10 mM | 0.6487 mL | 3.2434 mL | 6.4868 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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