| Size | Price | Stock | Qty |
|---|---|---|---|
| 10g |
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| Other Sizes |
| Targets |
Mecysteine hydrochloride does not have a specific molecular target in the classical sense of enzyme or receptor inhibition. Its primary action is physicochemical, acting as a mucolytic agent to reduce the viscosity of respiratory mucus. It is a thiol-containing amino acid derivative and a potent antioxidant. It also inhibits the binding of ethynylestradiol metabolites to protein and nucleic acids.
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|---|---|
| ln Vitro |
In vitro, me cysteine hydrochloride is a biochemical used to inhibit the binding of ethynylestradiol metabolites to proteins and nucleic acids. Its activity as a mucolytic is characterized by its ability to reduce the viscosity of mucus samples. It is also evaluated for its antioxidant properties in various cell-free assays, showing potential therapeutic effects.
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| ln Vivo |
In vivo, me cysteine hydrochloride increases the output of respiratory tract fluid in anesthetized dogs. As an expectorant and antitussive agent, it is used to relieve breathing difficulties caused by excessive mucus production. It is administered to facilitate the removal of mucus, making it easier to cough up and clear the airways.
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| Enzyme Assay |
In vitro enzyme/receptor binding studies are not typically performed for me cysteine hydrochloride, as its mechanism is not based on enzyme or receptor binding. Its mucolytic activity is evaluated using physicochemical assays measuring the reduction in mucus viscosity. Standard protocols involve mixing the compound with artificial or biological mucus preparations and assessing rheological properties using viscometers or rheometers.
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| Cell Assay |
In vitro cellular assays for me cysteine hydrochloride are not standard, as its mechanism is physicochemical rather than receptor-mediated. When cellular assays are conducted, they generally focus on its antioxidant properties or its ability to inhibit the binding of metabolites to proteins and nucleic acids in cell lysates. Cytotoxicity and cell viability may also be assessed using standard assays like MTT.
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| Animal Protocol |
In vivo animal studies for me cysteine hydrochloride involve anesthetized dogs to measure respiratory tract fluid output. Standard protocols involve administering the compound and collecting and measuring the volume of respiratory secretions. These studies help confirm its efficacy as a mucolytic agent. Toxicity and pharmacokinetic parameters may also be assessed in animal models.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of me cysteine hydrochloride include its rapid absorption and metabolism. As a methyl ester of L-cysteine, it is likely hydrolyzed to L-cysteine in vivo. It has a molecular weight of 171.65 and a molecular formula of C₄H₁₀ClNO₂S. It is soluble in DMSO and water. Detailed pharmacokinetic parameters such as half-life and clearance are not extensively documented.
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| Toxicity/Toxicokinetics |
Toxicological data for me cysteine hydrochloride indicate that it is generally well-tolerated at therapeutic doses. As a thiol-containing compound, it may cause gastrointestinal upset in some individuals. It is considered safe for use as a mucolytic agent. Standard safety assessments confirm its acceptable profile for human use in respiratory care. It is not intended for use in patients with known hypersensitivity.
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| Additional Infomation |
L-cysteine methyl ester is a product of the condensation of the carboxylic acid group of L-cysteine with methanol. It (in hydrochloride form) is used as an expectorant to treat respiratory illnesses accompanied by cough with phlegm. It has expectorant properties. It is an L-cysteine ester, a primary amino compound, and a thiol. Its function is related to L-cysteine and methanol.
Mecysteine hydrochloride is a mucolytic agent used for the treatment of respiratory disorders associated with productive cough. It is also known as Chistait and is available as a hydrochloride salt. It is a methyl ester of the conditionally essential amino acid L-cysteine. Its role as an expectorant makes it useful for relieving dyspnea caused by large amounts of phlegm. It is not approved for human therapeutic use in all jurisdictions. |
| Molecular Formula |
C4H10CLNO2S
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|---|---|
| Molecular Weight |
171.63
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| Exact Mass |
171.012
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| CAS # |
18598-63-5
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| PubChem CID |
29145
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| Appearance |
White to off-white solid powder
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| Boiling Point |
197.2ºC at 760 mmHg
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| Melting Point |
142 °C (dec.)(lit.)
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| Flash Point |
73.1ºC
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| Vapour Pressure |
0.384mmHg at 25°C
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| Index of Refraction |
-2.5 ° (C=20, MeOH)
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| LogP |
0.918
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
8
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| Complexity |
86.1
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| Defined Atom Stereocenter Count |
1
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| SMILES |
Cl[H].S([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])N([H])[H]
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| InChi Key |
MCYHPZGUONZRGO-VKHMYHEASA-N
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| InChi Code |
InChI=1S/C4H9NO2S/c1-7-4(6)3(5)2-8/h3,8H,2,5H2,1H3/t3-/m0/s1
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| Chemical Name |
methyl (2R)-2-amino-3-sulfanylpropanoate
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| Synonyms |
Mecysteine HCl; Chistait; Mecysteine hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~582.58 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.56 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.56 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8265 mL | 29.1324 mL | 58.2649 mL | |
| 5 mM | 1.1653 mL | 5.8265 mL | 11.6530 mL | |
| 10 mM | 0.5826 mL | 2.9132 mL | 5.8265 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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