| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Maoecrystal A does not have a single defined molecular target but exerts its effects through multiple mechanisms. Research indicates that it induces apoptosis, disrupts tumor cell proliferation, and modulates signaling pathways involved in cancer progression. It also exhibits anti-inflammatory and antioxidant activities. Its intricate polycyclic structure makes it an important subject in synthetic organic chemistry.
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| ln Vitro |
In vitro, Maoecrystal A induces apoptosis and disrupts tumor cell proliferation. It modulates signaling pathways involved in cancer progression. The compound exhibits anti-inflammatory, antioxidant, and antibacterial activities. It has been studied for its antitumor effects in various cancer cell lines. Its activity is dose-dependent and has been validated in multiple in vitro models.
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| ln Vivo |
In vivo, Maoecrystal A has been studied for its antitumor, anti-inflammatory, and antibacterial effects. It can be used for antitumor effect experiments. The compound's anti-inflammatory activities suggest potential therapeutic applications. Further in vivo studies are needed to fully characterize its pharmacokinetic properties and therapeutic potential.
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| Enzyme Assay |
In vitro cytotoxicity assays for Maoecrystal A are performed using various cancer cell lines. Cells are treated with Maoecrystal A at various concentrations for defined time periods. Cell viability is assessed using MTT or CellTiter-Glo assays. Apoptosis is measured by Annexin V/PI staining or caspase-3 activity assays. Cell cycle analysis is performed by flow cytometry. Anti-inflammatory activity is assessed by measuring cytokine production in immune cells.
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| Cell Assay |
In vitro cellular studies are conducted using cancer cell lines and immune cells. Cells are treated with Maoecrystal A at various concentrations. Cell proliferation, apoptosis, and cell cycle progression are assessed. Inflammatory markers such as cytokines and ROS are measured. Antibacterial activity is assessed by measuring minimum inhibitory concentrations (MIC) against various pathogens. Signaling pathways are analyzed by Western blot.
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| Animal Protocol |
In vivo animal experiments with Maoecrystal A are limited. The compound is a natural product with potential therapeutic applications. Further in vivo studies are needed to evaluate its efficacy in cancer, inflammation, and infection models. Animals would be administered Maoecrystal A via injection or oral gavage, and endpoints would include tumor growth inhibition, inflammation reduction, and bacterial clearance.
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| ADME/Pharmacokinetics |
Maoecrystal A has a molecular formula of C22H28O6 and a molecular weight of 388.45 g/mol. It is an ent-kaurane-type diterpene. For storage, it should be kept at 2-8°C, protected from light and sealed to prevent degradation. The compound is a primary metabolite belonging to the group of phytochemicals. It is supplied as a research-grade compound. It should be stored in an amber vial under an inert atmosphere.
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| Toxicity/Toxicokinetics |
As a research chemical with potent biological activity, Maoecrystal A is not intended for human use. Its toxicological profile is not fully characterized. Standard laboratory safety precautions should be followed when handling it. Its effects on blood pressure and smooth muscle suggest potential cardiovascular effects at high doses.
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| References | |
| Additional Infomation |
According to reports, hair-like crystal A exists in Isodon eriocalyx and Isodon, and there is relevant data.
Maoecrystal A is also known as 毛萼晶A. It is a natural compound isolated from the leaves of I. eriocalyx with anti-inflammatory, antioxidant, and antibacterial activities. It induces apoptosis, disrupts tumor cell proliferation, and modulates signaling pathways involved in cancer progression. The compound is used in research on cancer, inflammation, and infectious diseases. |
| Molecular Formula |
C22H28O6
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|---|---|
| Molecular Weight |
388.4541
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| Exact Mass |
388.188
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| CAS # |
96850-30-5
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| PubChem CID |
20056131
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
550.8±50.0 °C at 760 mmHg
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| Flash Point |
191.1±23.6 °C
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| Vapour Pressure |
0.0±3.4 mmHg at 25°C
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| Index of Refraction |
1.579
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| LogP |
2
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
28
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| Complexity |
814
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| Defined Atom Stereocenter Count |
8
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| SMILES |
CC(=O)O[C@@H]1C(=C)[C@@H]2CC[C@@H]3[C@]1(C2)C(=O)[C@H]([C@H]4[C@]35CO[C@@H](C4(C)C)CC5=O)O
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| InChi Key |
DCULYKVTBAXAER-XETVFITMSA-N
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| InChi Code |
InChI=1S/C22H28O6/c1-10-12-5-6-13-21(8-12,19(10)28-11(2)23)18(26)16(25)17-20(3,4)15-7-14(24)22(13,17)9-27-15/h12-13,15-17,19,25H,1,5-9H2,2-4H3/t12-,13-,15-,16+,17-,19-,21-,22-/m1/s1
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| Chemical Name |
[(1S,2S,5R,7R,8S,10S,11R,13R)-10-hydroxy-12,12-dimethyl-6-methylidene-9,16-dioxo-14-oxapentacyclo[11.2.2.15,8.01,11.02,8]octadecan-7-yl] acetate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~85.80 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5743 mL | 12.8717 mL | 25.7433 mL | |
| 5 mM | 0.5149 mL | 2.5743 mL | 5.1487 mL | |
| 10 mM | 0.2574 mL | 1.2872 mL | 2.5743 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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