| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| ln Vitro |
Malotiate has the ability to decrease fibroblasts' in vitro cell migratory activity and collagen production [3]. Malotiate is an antifibrotic agent that concurrently promotes the 12- and 15-lipoxygenase pathways while selectively inhibiting 5-lipoxygenase. It has been demonstrated that malotiate protects against acute experimental liver damage brought on by a number of hepatotoxic substances, such as thioacetamide, carbon tetrachloride, ethanol, bromobenzene, and chloroform.
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|---|---|
| ln Vivo |
Serum cholesterol levels quickly returned to normal after malotiate (100 mg/kg) was given orally to hypocholesterolemic rats once a day for three days [5].
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| Animal Protocol |
Animal/Disease Models: SLC-SD strain male rats (rats with liver damage caused by carbon tetrachloride) [5]
Doses: 100 mg/kg Route of Administration: Po; one time/day for 3 days Experimental Results: Rats given CCI4 Hepatic triglyceride secretion was inhibited to approximately 40% of the levels in control rats. This suppression of triglyceride secretion completely normalized after 3 days of administration of malotiate. |
| References |
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| Additional Infomation |
Malotilate is an isopropyl ester.
|
| Molecular Formula |
C12H16O4S2
|
|---|---|
| Molecular Weight |
288.376
|
| Exact Mass |
288.049
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| CAS # |
59937-28-9
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| PubChem CID |
4006
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
321.5±42.0 °C at 760 mmHg
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| Flash Point |
138.7±15.9 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.562
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| LogP |
3.83
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
18
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| Complexity |
363
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
YPIQVCUJEKAZCP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3
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| Chemical Name |
dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate
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| Synonyms |
NKK 105; CL-1500; Malotilate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~346.76 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.67 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.67 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4676 mL | 17.3382 mL | 34.6765 mL | |
| 5 mM | 0.6935 mL | 3.4676 mL | 6.9353 mL | |
| 10 mM | 0.3468 mL | 1.7338 mL | 3.4676 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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