| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| ln Vitro |
Mab PanDE119A, Mab PanDS135A, and Mab PanDY126A mutants are inhibited by Mab Aspartate Decarboxylase-IN-1 (compound analogue 2), with inhibition rates of 70.5%, 74.4%, and 81.8%, respectively [1]. With an IC50 value of 56.3±4.8 µM, Mab Aspartate Decarboxylase-IN-1 (0-200 µM) transforms l-Asp into β-Ala and inhibits the PanD enzyme activity of Mycobacterium abscessus (Mab)[1]. Mycobacterium abscessus subsp. is susceptible to the antibacterial activity of Mab Aspartate Decarboxylase-IN-1 (0–4 mM). The IC50 value of Mycobacterium abscessus ATCC 19977 and Mycobacterium abscessus subsp. is 0.7 mM. Bolletii, Mycobacterium abscessus subsp. CCUG 48898T, Massiliense; Mycobacterium abscessus subsp. M. abscessus, M. abscessus subsp. IC50 for Abscess ATCC 19977 is 1-2 mM [1]. The primary interactions that Mab Aspartate Decarboxylase-IN-1 displays with the target enzyme are hydrogen bonding and electrostatic [1].
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| References |
[1]. Saw WG, et al. Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor. ACS Infect Dis. 2022 Jul 8;8(7):1324-1335.
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| Molecular Formula |
C16H11N3O3
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|---|---|
| Molecular Weight |
293.276843309402
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| Exact Mass |
293.08
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| CAS # |
2755712-12-8
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| PubChem CID |
164886636
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
2.6
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
22
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| Complexity |
429
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
LYCKJICKYNNXMU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H11N3O3/c20-15(19-14-13(16(21)22)17-8-9-18-14)12-7-3-5-10-4-1-2-6-11(10)12/h1-9H,(H,21,22)(H,18,19,20)
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| Chemical Name |
3-(naphthalene-1-carbonylamino)pyrazine-2-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~16.67 mg/mL (~56.84 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.67 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.67 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4097 mL | 17.0486 mL | 34.0971 mL | |
| 5 mM | 0.6819 mL | 3.4097 mL | 6.8194 mL | |
| 10 mM | 0.3410 mL | 1.7049 mL | 3.4097 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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