| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
| Other Sizes |
| Targets |
Lup-20(29)-en-28-al, 3β-hydroxy- targets various cellular pathways involved in inflammation and cancer. It has been shown to inhibit topoisomerase and induce apoptosis in cancer cells. The compound also modulates inflammatory signaling pathways.
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|---|---|
| ln Vitro |
In vitro, lup-20(29)-en-28-al, 3β-hydroxy- exhibits antiproliferative activity against various cancer cell lines. It induces apoptosis and inhibits cell migration. The compound also shows anti-inflammatory activity by reducing cytokine production.
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| ln Vivo |
In vivo, lup-20(29)-en-28-al, 3β-hydroxy- has been studied in animal models of cancer and inflammation. It shows efficacy in reducing tumor growth and inflammation. The compound is a natural product with potential therapeutic applications.
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| Enzyme Assay |
In vitro enzyme assays measure the inhibition of topoisomerase or other enzymes by lup-20(29)-en-28-al, 3β-hydroxy-. The compound is incubated with the enzyme and a substrate, and enzyme activity is measured. The IC50 is determined from dose-response curves.
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| Cell Assay |
In vitro cellular assays evaluate the antiproliferative and apoptotic effects of lup-20(29)-en-28-al, 3β-hydroxy- on cancer cell lines. Cells are treated with the compound, and cell viability is assessed using MTT or similar assays. Apoptosis is detected by Annexin V staining or caspase activity assays.
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| Animal Protocol |
In vivo animal experiments are conducted in mouse xenograft models of cancer or in models of inflammation. Lup-20(29)-en-28-al, 3β-hydroxy- is administered, and tumor growth or inflammation is assessed.
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| ADME/Pharmacokinetics |
Lup-20(29)-en-28-al, 3β-hydroxy- has a molecular formula of C30H48O2 and a molecular weight of 440.70. It has a CAS number of 13159-28-9. The compound is a natural triterpenoid derived from betulin.
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| Toxicity/Toxicokinetics |
The toxicity profile of lup-20(29)-en-28-al, 3β-hydroxy- is not well documented. As a natural product, it is expected to have a moderate safety profile, but comprehensive toxicological studies are lacking.
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| References |
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| Additional Infomation |
Lup-20(29)-en-28-al, 3β-hydroxy- is a triterpenoid compound. It has been reported that betulin has been found in Diospyros eriantha, Diospyros maritima, and other organisms with relevant data.
Lup-20(29)-en-28-al, 3β-hydroxy- is a natural triterpenoid with pharmacological activities. It is a precursor to betulinic acid and other bioactive compounds. It is used in research on cancer, inflammation, and infectious diseases. |
| Molecular Formula |
C30H48O2
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|---|---|
| Molecular Weight |
440.7009
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| Exact Mass |
440.365
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| CAS # |
13159-28-9
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| PubChem CID |
99615
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
513.9±33.0 °C at 760 mmHg
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| Flash Point |
217.4±18.0 °C
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| Vapour Pressure |
0.0±3.0 mmHg at 25°C
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| Index of Refraction |
1.545
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| LogP |
9.07
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
32
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| Complexity |
814
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| Defined Atom Stereocenter Count |
10
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| SMILES |
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C=O
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| InChi Key |
FELCJAPFJOPHSD-ROUWMTJPSA-N
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| InChi Code |
InChI=1S/C30H48O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h18,20-25,32H,1,8-17H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
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| Chemical Name |
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carbaldehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~20 mg/mL (~45.38 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2 mg/mL (4.54 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2 mg/mL (4.54 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | |
| 5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | |
| 10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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