| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Lufenuron targets chitin synthesis in insects and other arthropods. It inhibits the production of chitin, a key component of the exoskeleton. By disrupting chitin synthesis, it prevents insects from developing proper exoskeletons during molting. This leads to the death of the insect during the molting process. Unlike conventional neurotoxic insecticides, Lufenuron has a unique mechanism of action that targets the insect's growth and development.
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| ln Vitro |
Lufenuron is a chitin synthesis inhibitor. It inhibits molting in arthropods. Its activity has been confirmed in various insect bioassays. It is effective against a wide range of insect pests, including fleas, fish lice, and Lepidoptera. Its lipophilic nature allows it to penetrate the insect cuticle and reach its target site.
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| ln Vivo |
Lufenuron is used in veterinary medicine for flea control. It is administered orally to dogs and cats, where it is absorbed and distributed to the skin and hair follicles. When fleas feed on the treated animal, they ingest the compound, which inhibits chitin synthesis in the flea eggs and larvae, preventing the flea life cycle from completing. It is also used in aquaculture for fish lice control.
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| Enzyme Assay |
Lufenuron does not have a typical enzyme/receptor binding assay. Its activity is assessed in insect bioassays. Insects or their eggs are exposed to the compound, and the inhibition of molting, egg hatching, or development is measured. The effects on chitin synthesis can be assessed by measuring chitin content in treated insects.
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| Cell Assay |
Lufenuron is not typically used in cell-based assays for pharmacological activity. Its effects are studied in insect models. The compound's effects on insect cell lines can be assessed by measuring chitin synthesis or cell viability. However, its primary applications are in pest control rather than cellular research.
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| Animal Protocol |
In vivo animal experiments for Lufenuron are conducted in dogs, cats, and other animals for flea control. The compound is administered orally, and its efficacy in preventing flea infestations is assessed. Its safety and pharmacokinetic properties in animals are also evaluated. In aquaculture, it is tested in fish for fish lice control.
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| ADME/Pharmacokinetics |
Lufenuron has a molecular weight of 511.15 g/mol and a molecular formula of C17H8Cl2F8N2O3. It is a lipophilic compound. It is practically insoluble in water but soluble in organic solvents. It has a long residual effectiveness. It is stable under normal conditions and is typically used as a solid formulation for oral administration in veterinary applications.
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| Toxicity/Toxicokinetics |
Lufenuron has low toxicity to mammals. It is well-tolerated in dogs and cats at the recommended doses. It is not intended for human use. In animals, it is generally safe, but mild gastrointestinal upset may occur. It is contraindicated in animals with known hypersensitivity to the compound. Its safety has been established in veterinary applications.
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| Additional Infomation |
Lufenuron is a benzoylurea insecticide belonging to the dichlorobenzene, N-acylurea, aromatic ether, and organofluorine compounds class. Lufenuron is used in veterinary medicine to control fleas. See also: Lufenuron; milbemime (ingredient); Lufenuron; milbemime; praziquantel (ingredient); Lufenuron; nitropyridine (ingredient)... See more...
Lufenuron is a lipophilic benzoylurea insecticide and chitin synthesis inhibitor used for flea and fish lice control. It inhibits molting in arthropods by disrupting chitin synthesis. It is administered orally in veterinary medicine for flea control and is also used in aquaculture. Lufenuron is available from various chemical suppliers for research and veterinary purposes. |
| Molecular Formula |
C17H8CL2F8N2O3
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|---|---|
| Molecular Weight |
511.1492
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| Exact Mass |
509.978
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| CAS # |
103055-07-8
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| Related CAS # |
Lufenuron-13C6
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| PubChem CID |
71777
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.6±0.1 g/cm3
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| Melting Point |
175 °C
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| Flash Point |
170 °C
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| Index of Refraction |
1.523
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| LogP |
6.27
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
32
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| Complexity |
677
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC1=CC=CC(F)=C1C(NC(NC2=C(Cl)C=C(OC(F)(F)C(F)C(F)(F)F)C(Cl)=C2)=O)=O
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| InChi Key |
PWPJGUXAGUPAHP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H8Cl2F8N2O3/c18-6-5-11(32-17(26,27)14(22)16(23,24)25)7(19)4-10(6)28-15(31)29-13(30)12-8(20)2-1-3-9(12)21/h1-5,14H,(H2,28,29,30,31)
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| Chemical Name |
N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
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| Synonyms |
CGA 184699; Fluphenacur; Lufenuron
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~244.55 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.07 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.07 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9564 mL | 9.7819 mL | 19.5637 mL | |
| 5 mM | 0.3913 mL | 1.9564 mL | 3.9127 mL | |
| 10 mM | 0.1956 mL | 0.9782 mL | 1.9564 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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