| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
The dissociation rate of 125I-AB-MECA from A3 receptors in CHO cell membranes is halved by 2.5 times with LUF6096 (10 μM; 30-120 minutes) [1]. Forskolin-stimulated cAMP generation in CHO cells can be inhibited and the intrinsic activity of Cl-IB-MECA considerably enhanced by LUF6096 (10 μM; 15 min pretreatment) [1].
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| ln Vivo |
In dogs, myocardial ischemia/reperfusion damage is prevented by LUF6096 (two intravenous bolus doses of 0.5 mg/kg or a single intravenous bolus dosage of 1 mg/kg) [1].
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| Animal Protocol |
Animal/Disease Models: Adult mongrel dogs (15-25 kg) underwent left anterior descending (LAD) coronary artery occlusion and reperfusion [1]
Doses: Two intravenous (iv) (iv)bolus injections of 0.5 mg/kg or a single intravenous (iv) (iv)bolus of 1 mg/kg given Medication: intravenous (iv) (iv)bolus Experimental Results: Infarct size was Dramatically diminished (approximately 50% reduction) compared to vehicle-treated dogs. |
| References |
[1]. Heitman LH, et, al. A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. J Med Chem. 2009 Feb 26;52(4):926-31.
[2]. Du L, et, al. Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor. J Pharmacol Exp Ther. 2012 Jan;340(1):210-7. |
| Molecular Formula |
C22H21CL2N3O
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|---|---|
| Molecular Weight |
414.33
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| Exact Mass |
413.106
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| CAS # |
1116652-18-6
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| Related CAS # |
1116652-18-6;
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| PubChem CID |
25191023
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
6.875
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
28
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| Complexity |
528
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC=1C=CC(=CC1Cl)N=C2NC3=CC=CC=C3C(=C2)NC(C4CCCCC4)=O
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| InChi Key |
UWEIQVQNNLVOEI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H21Cl2N3O/c23-17-11-10-15(12-18(17)24)25-21-13-20(16-8-4-5-9-19(16)26-21)27-22(28)14-6-2-1-3-7-14/h4-5,8-14H,1-3,6-7H2,(H2,25,26,27,28)
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| Chemical Name |
N-[2-[(3,4-Dichlorophenyl)amino]-4-quinolinyl]-cyclohexanecarboxamide
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| Synonyms |
LUF6096 LUF 6096LUF-6096CF-602 CF602 CF 602
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~20 mg/mL (~48.27 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4135 mL | 12.0677 mL | 24.1354 mL | |
| 5 mM | 0.4827 mL | 2.4135 mL | 4.8271 mL | |
| 10 mM | 0.2414 mL | 1.2068 mL | 2.4135 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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