| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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Loureirin A, a naturally occurring di-hydrochalcone/flavonoid isolated from Dragon's Blood, can inhibit Akt phosphorylation and has antiplatelet activity. It has been used to promote blood circulation and remove stasis in Chinese traditional medicine.
| ln Vitro |
In a dose-dependent manner, loureirin A (50 μM, 100 μM) suppresses the release of platelet ATP produced by collagen and the expression of P-selectin activated by thrombin. Additionally, with immobilized fibrinogen, loureirin A dramatically reduces platelet spreading. At a dosage of 100 μM, luminirin A nearly entirely removes collagen-induced Akt phosphorylation at Ser473, and at 50 μM, it exhibits an additive inhibitory effect when combined with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets[1].
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| References | |
| Additional Infomation |
Loureirin A has been reported in Dracaena cochinchinensis, Soymida febrifuga, and Garcinia dulcis with data available.
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| Molecular Formula |
C17H18O4
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|---|---|
| Molecular Weight |
286.3224
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| Exact Mass |
286.12
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| CAS # |
119425-89-7
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| PubChem CID |
5319081
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
479.1±40.0 °C at 760 mmHg
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| Flash Point |
175.8±20.8 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.573
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| LogP |
3.3
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
21
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| Complexity |
323
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
RSAIVLRELNGZEY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H18O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-5,7-9,11,18H,6,10H2,1-2H3
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| Chemical Name |
3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 86.6 mg/mL (~302.46 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4926 mL | 17.4630 mL | 34.9260 mL | |
| 5 mM | 0.6985 mL | 3.4926 mL | 6.9852 mL | |
| 10 mM | 0.3493 mL | 1.7463 mL | 3.4926 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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