| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
Liquiritoside targets various molecular targets, including inflammatory mediators, oxidative stress pathways, and neurotransmitter systems. The compound has antioxidant, anti-inflammatory, and neuroprotective effects. Its mechanism of action involves the inhibition of pro-inflammatory cytokines, scavenging of free radicals, and modulation of neurotransmitter signaling. Liquiritoside's multi-targeted effects make it a valuable tool for studying natural product pharmacology.
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| ln Vitro |
The AKR1C1 residues Asn-56, Ala-27, Val-29, and Ala-25 can all be inhibited by liquidritin [1]. In HEC-1-B cells, liquidritin (50 μM; 6 hours) led to an 85.00% decrease in progesterone consumption, which was mediated by the activity of the enzyme aldehyde-keto reductase family 1 member C1 (AKR1C1) [1]. On B65 neuroblastoma tumor cells, liquidritin (100 μM) stimulates the expression of important 6-phosphate dehydrogenase [2].
In vitro, liquiritoside exhibits antioxidant, anti-inflammatory, and neuroprotective activities. It inhibits the production of pro-inflammatory cytokines, scavenges free radicals, and protects neuronal cells from damage. In cell-based assays, liquiritoside treatment results in reduced inflammation, decreased oxidative stress, and improved cell survival. These studies confirm the compound's diverse pharmacological activities. |
| ln Vivo |
In vivo, liquiritoside has been studied for its potential in the treatment of inflammation, oxidative stress, and neurological disorders. The compound's anti-inflammatory and antioxidant effects have been demonstrated in animal models of inflammation and oxidative stress. Neuroprotective effects have been shown in models of neurological disorders. Comprehensive in vivo studies are needed to fully characterize its therapeutic potential.
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| Enzyme Assay |
In vitro enzyme assays for liquiritoside involve measuring its antioxidant activity using DPPH or ABTS assays. The compound's anti-inflammatory activity is assessed by measuring the inhibition of COX or LOX enzymes. These assays confirm the compound's mechanism of action.
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| Cell Assay |
In vitro cell-based assays for liquiritoside evaluate its effects on inflammation and oxidative stress. Cells such as macrophages are cultured and treated with liquiritoside, and the production of inflammatory mediators is measured by ELISA. Oxidative stress is assessed by measuring ROS production. These assays confirm the compound's functional activity.
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| Animal Protocol |
In vivo animal experiments for liquiritoside have been conducted in models of inflammation and neurological disorders. Animals are treated with liquiritoside, and inflammatory markers and behavioral outcomes are assessed. Pharmacokinetic studies are conducted to determine the compound's half-life and tissue distribution. Comprehensive in vivo studies are ongoing.
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| ADME/Pharmacokinetics |
Liquiritoside is absorbed after oral administration and is metabolized to liquiritigenin. It is excreted in urine and feces. The compound has a molecular weight of 418.39 g/mol. It is soluble in organic solvents and slightly soluble in water. Liquiritoside is for research use only.
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| Toxicity/Toxicokinetics |
The toxicity of liquiritoside is low. It is a natural compound found in licorice. High doses may cause adverse effects. Liquiritoside is for research use only.
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| References |
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| Additional Infomation |
Liquiritin is a flavanone glycoside composed of Liquiritin linked by a glycosidic bond to a β-D-glucopyranose residue at the 4' position. It is a plant metabolite with anticoronavirus and anti-inflammatory activities. It is a flavanone glycoside, β-D-glucoside, monosaccharide derivative, and monohydroxyflavanone. Its function is related to that of Liquiritin. Liquiritin has been reported in licorice (Glycyrrhiza uralensis), licorice (Glycyrrhiza aspera), and other organisms with relevant data. See also: Glycyrrhiza glabra (partial); Glycyrrhiza uralensis root (partial).
Liquiritoside (Liquiritin) is a flavonoid glycoside found in the roots of Glycyrrhiza species (licorice). It has a molecular formula of C₂₁H₂₂O₉ and a molecular weight of 418.39 g/mol. Liquiritoside is the glucoside of liquiritigenin, a flavonoid with antioxidant, anti-inflammatory, and neuroprotective properties. The compound has been studied for its potential in the treatment of various diseases. Liquiritoside is a valuable research tool for studying flavonoid pharmacology. |
| Molecular Formula |
C21H22O9
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| Molecular Weight |
418.39
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| Exact Mass |
418.126
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| CAS # |
551-15-5
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| PubChem CID |
503737
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
746.8±60.0 °C at 760 mmHg
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| Melting Point |
212 °C
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| Flash Point |
265.9±26.4 °C
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| Vapour Pressure |
0.0±2.6 mmHg at 25°C
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| Index of Refraction |
1.670
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| LogP |
0.61
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
30
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| Complexity |
593
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| Defined Atom Stereocenter Count |
6
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| SMILES |
C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
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| InChi Key |
DEMKZLAVQYISIA-ZRWXNEIDSA-N
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| InChi Code |
InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
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| Chemical Name |
(S)-7-hydroxy-2-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)chroman-4-one
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| Synonyms |
Liquiritoside Liquiritin Likviritin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~150 mg/mL (~358.52 mM)
H2O : < 0.1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | |
| 5 mM | 0.4780 mL | 2.3901 mL | 4.7802 mL | |
| 10 mM | 0.2390 mL | 1.1951 mL | 2.3901 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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