| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
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| Targets |
Lindenenol does not have a single defined molecular target. Its biological activity is primarily attributed to its antioxidant properties, which involve scavenging free radicals and reducing oxidative stress. Its antibacterial activity suggests it may interact with bacterial cell components, though the exact mechanism is not fully defined.
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|---|---|
| ln Vitro |
In vitro, lindenenol has demonstrated antioxidant activity, likely through its ability to scavenge free radicals. It also exhibits antibacterial activity against various bacterial strains. These in vitro activities confirm its potential as a natural antioxidant and antimicrobial agent.
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| ln Vivo |
Detailed in vivo activity data for lindenenol are not extensively provided in the search results. However, its antioxidant and antibacterial properties suggest potential for in vivo efficacy in models of oxidative stress and infection. Further studies are needed to confirm its therapeutic potential.
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| Enzyme Assay |
Non-cell-based assays for lindenenol would typically involve measuring its antioxidant activity in cell-free systems using assays such as DPPH radical scavenging or ABTS radical cation decolorization. Its antibacterial activity can be assessed using standard broth microdilution or agar diffusion methods.
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| Cell Assay |
Cellular assays for lindenenol are performed using bacterial cultures to assess its antibacterial activity. Bacteria are cultured in appropriate medium and treated with lindenenol at various concentrations. Bacterial growth is assessed by optical density measurement or colony counting. For antioxidant studies, cells are treated with lindenenol and exposed to oxidative stress, and cell viability is measured.
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| Animal Protocol |
In vivo animal models for lindenenol would likely involve the use of mice in models of bacterial infection or oxidative stress. The compound would be administered, and its effects on bacterial load, tissue damage, or oxidative stress markers would be assessed.
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| ADME/Pharmacokinetics |
Lindenenol has a molecular weight of 230.30 g/mol and a molecular formula of C15H18O2. It is a furanosesquiterpenoid that is soluble in DMSO. Detailed PK parameters such as half-life and bioavailability are not extensively detailed in the provided search results.
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| Toxicity/Toxicokinetics |
Detailed toxicological data for lindenenol are not provided in the search results. As a natural product, it is generally considered to have a good safety profile, but thorough toxicological studies would be required for therapeutic development. The compound is intended for research use only and is not for human consumption.
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| References | |
| Additional Infomation |
Lindelenols are benzofuran compounds. Lindelenols have been reported to exist in Lindera pulcherrima var. hemsleyana and Lindera chunii, and relevant data are available.
Lindenenol is also known as Linderene. It is a furanosesquiterpenoid isolated from Radix Linderae. It has antioxidant and antibacterial activities. It has the CAS number 26146-27-0 and is supplied for research purposes as a natural product. |
| Molecular Formula |
C15H18O2
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|---|---|
| Molecular Weight |
230.3022
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| Exact Mass |
230.13
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| CAS # |
26146-27-0
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| PubChem CID |
497203
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
265.4±30.0 °C at 760 mmHg
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| Melting Point |
145-147℃ (methanol )
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| Flash Point |
114.3±24.6 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.596
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| LogP |
3.1
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
17
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| Complexity |
390
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| Defined Atom Stereocenter Count |
5
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| SMILES |
CC1=COC2=C1[C@@H]([C@H]3C(=C)[C@H]4C[C@H]4[C@@]3(C2)C)O
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| InChi Key |
XRDJYSVGPBJZSG-PSDLAXTLSA-N
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| InChi Code |
InChI=1S/C15H18O2/c1-7-6-17-11-5-15(3)10-4-9(10)8(2)13(15)14(16)12(7)11/h6,9-10,13-14,16H,2,4-5H2,1,3H3/t9-,10-,13-,14+,15+/m1/s1
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| Chemical Name |
(1S,2R,9S,10R,12S)-4,9-dimethyl-13-methylidene-6-oxatetracyclo[7.4.0.03,7.010,12]trideca-3(7),4-dien-2-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~434.22 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (10.86 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (10.86 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3422 mL | 21.7108 mL | 43.4216 mL | |
| 5 mM | 0.8684 mL | 4.3422 mL | 8.6843 mL | |
| 10 mM | 0.4342 mL | 2.1711 mL | 4.3422 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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