| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Linalool oxide does not have a specific biological target in the traditional pharmacological sense. As a volatile terpenoid, it interacts with olfactory receptors, contributing to its characteristic floral, woody, and slightly sweet odor. The compound may also have antimicrobial and insect repellent properties, which are related to its lipophilic nature and its ability to disrupt cell membranes. However, its primary utility is in flavor, fragrance, and natural product research rather than pharmacology.
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| ln Vitro |
Linalool oxide exhibits antimicrobial activity in vitro against various bacteria and fungi. The compound also has insect repellent properties, affecting the behavior of various insect species. Linalool oxide's antimicrobial and insect repellent activities are related to its lipophilic nature. The compound also has antioxidant activity, as it can scavenge free radicals. Specific IC₅₀ values for various activities are not extensively documented.
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| ln Vivo |
Linalool oxide does not have significant in vivo pharmacological activity. It is a volatile compound that is rapidly metabolized and eliminated from the body. The compound is not used as a therapeutic agent and is not administered to animals for pharmacological studies. Its use is limited to flavor, fragrance, and natural product research.
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| Enzyme Assay |
Non-cellular assays for linalool oxide typically involve measuring its antioxidant activity using chemical assays such as DPPH, ABTS, or FRAP. The compound's ability to scavenge free radicals is measured spectrophotometrically. Antimicrobial activity can be assessed using disk diffusion or broth microdilution assays. For insect behavior studies, olfactometer assays or choice tests are used to assess the compound's attractiveness or repellency to insects.
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| Cell Assay |
In vitro cellular assays for linalool oxide are not typically conducted for pharmacological evaluation. The compound may be used in cell culture experiments to study its effects on cell viability or oxidative stress, but such studies are not standard. Its primary use is in flavor, fragrance, and natural product research.
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| Animal Protocol |
Linalool oxide is not used in in vivo animal studies as a therapeutic or pharmacological agent. Its application is limited to research on flavor and fragrance compounds and plant-insect interactions. The compound may be used in behavioral assays with insects to study the effects of volatile organic compounds on insect behavior.
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| ADME/Pharmacokinetics |
Linalool oxide is not a drug and does not have pharmacokinetic properties. Its physical and chemical properties are more relevant: it is a cyclic ether with a molecular weight of 170.25 and a molecular formula of C₁₀H₁₈O₂. The compound is a colorless liquid with a floral, woody odor. It is soluble in organic solvents and has limited solubility in water.
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| Toxicity/Toxicokinetics |
Linalool oxide is considered to have low toxicity. It may cause skin and eye irritation upon contact. The compound is generally recognized as safe (GRAS) for use as a flavoring agent in food. However, standard laboratory safety precautions should be observed when handling this compound.
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| References |
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| Additional Infomation |
Linalool oxide is an oxacyclopentane compound. It has been reported that linalool oxide is found in tea (Camellia sinensis), Arabian wild pea (Pulicaria arabica), and papaya (Carica papaya), and relevant data are available for reference.
Linalool oxide is a research-grade natural product intended for laboratory use only and is not approved for clinical use. Its CAS number is 60047-17-8. The primary applications of linalool oxide include flavor and fragrance research, studies of natural product chemistry and plant-insect interactions, and as a reference standard for the analysis of volatile terpenoids. The compound is a valuable tool for flavor chemistry, natural product research, and insect behavior studies. |
| Molecular Formula |
C10H18O2
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|---|---|
| Molecular Weight |
170.24872
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| Exact Mass |
170.131
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| CAS # |
60047-17-8
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| PubChem CID |
22310
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.945 g/mL at 20 °C(lit.)
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| Boiling Point |
188°C
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| Melting Point |
128.30 °C. @ 0.00 mm Hg
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| Flash Point |
63°C
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| Index of Refraction |
n20/D 1.452
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| LogP |
1.881
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
12
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| Complexity |
186
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C=CC1(C)CCC(C(C)(C)O)O1
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| InChi Key |
BRHDDEIRQPDPMG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H18O2/c1-5-10(4)7-6-8(12-10)9(2,3)11/h5,8,11H,1,6-7H2,2-4H3
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| Chemical Name |
2-(5-ethenyl-5-methyloxolan-2-yl)propan-2-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~587.37 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8737 mL | 29.3686 mL | 58.7372 mL | |
| 5 mM | 1.1747 mL | 5.8737 mL | 11.7474 mL | |
| 10 mM | 0.5874 mL | 2.9369 mL | 5.8737 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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