| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
The specific molecular targets of Licoricesaponin G2 have not been well-characterized. As a triterpenoid saponin, it may interact with cell membranes, affecting membrane fluidity and permeability, and may modulate various cellular signaling pathways. Saponins are known for their ability to form complexes with cholesterol and other membrane components, which can affect cell membrane integrity and function. Licoricesaponin G2 may also have immunomodulatory, anti-inflammatory, or antioxidant activities, as other licorice saponins have been shown to possess these properties. However, specific studies on the molecular targets of Licoricesaponin G2 are lacking.
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| ln Vitro |
In vitro, the biological activities of Licoricesaponin G2 have not been extensively studied. As a saponin, it may have hemolytic activity, which is a common property of saponins due to their interaction with cell membranes. It may also have cytotoxic activity against cancer cell lines, similar to other licorice saponins. However, specific data on Licoricesaponin G2's in vitro activity are not available in the published literature.
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| ln Vivo |
In vivo, the biological activities of Licoricesaponin G2 have not been extensively studied. As a saponin, it may have low oral bioavailability due to its glycosidic structure and high molecular weight. The compound may be metabolized in the gut by intestinal bacteria to release the aglycone, which may be the active metabolite. However, specific in vivo studies on Licoricesaponin G2 are lacking in the available literature.
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| Enzyme Assay |
The non-cellular assay for Licoricesaponin G2 would likely involve the measurement of its hemolytic activity or its interaction with membranes. In a hemolytic assay, red blood cells are incubated with Licoricesaponin G2 at various concentrations, and the release of hemoglobin is measured spectrophotometrically. The compound's hemolytic activity is compared to that of a positive control (such as Triton X-100). However, specific protocols for Licoricesaponin G2 have not been reported.
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| Cell Assay |
The cellular assay for Licoricesaponin G2 would involve treating cultured cells with the compound and measuring its effects on cell viability, membrane integrity, or other cellular functions. However, specific protocols and data for Licoricesaponin G2 have not been reported in the available literature.
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| Animal Protocol |
In vivo animal studies for Licoricesaponin G2 have not been reported in the available literature. As a research compound, it may be studied in models of inflammation, cancer, or other diseases, but specific protocols and findings are lacking.
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| ADME/Pharmacokinetics |
Licoricesaponin G2 has a molecular weight of 838.93 g/mol and a molecular formula of C₄₂H₆₂O₁₇. The compound is a triterpenoid saponin with high molecular weight and polar glycosidic groups, which contribute to its hydrophilic character. It is soluble in water and polar organic solvents. The compound should be stored at 2-8°C, protected from light and moisture, and is stable for up to 24 months when stored properly.
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| Toxicity/Toxicokinetics |
The toxicological profile of Licoricesaponin G2 has not been extensively characterized. As a saponin, it may have hemolytic activity and can cause gastrointestinal disturbances at high doses. The compound should be handled with appropriate laboratory safety precautions.
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| References | |
| Additional Infomation |
Licoricesaponin G2 is a triterpenoid saponin. It has been reported to exist in licorice (Glycyrrhiza uralensis) and inflatable licorice (Glycyrrhiza inflata), and relevant data are available. See also: Licorice (Glycyrrhiza uralensis) root (part).
Licoricesaponin G2 is a pentacyclic triterpenoid saponin isolated from the roots of Glycyrrhiza species, including Glycyrrhiza uralensis, Glycyrrhiza inflata, and Glycyrrhiza aspera. It is one of many bioactive saponins found in licorice, a plant that has been used in traditional medicine for centuries. Licoricesaponin G2 is a research compound that is used to study the chemical composition and biological activities of licorice saponins. Further research is needed to fully characterize the pharmacological properties and potential therapeutic applications of Licoricesaponin G2. |
| Molecular Formula |
C42H62O17
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|---|---|
| Molecular Weight |
838.94
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| Exact Mass |
838.398
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| CAS # |
118441-84-2
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| PubChem CID |
14891565
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
1005.2±65.0 °C at 760 mmHg
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| Flash Point |
298.3±27.8 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.631
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| LogP |
3.05
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| Hydrogen Bond Donor Count |
9
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| Hydrogen Bond Acceptor Count |
17
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
59
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| Complexity |
1750
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| Defined Atom Stereocenter Count |
20
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| SMILES |
C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H]([C@]([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O
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| InChi Key |
WBQVRPYEEYUEBQ-OJVDLISWSA-N
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| InChi Code |
InChI=1S/C42H62O17/c1-37-11-12-38(2,36(54)55)16-19(37)18-15-20(44)31-39(3)9-8-22(40(4,17-43)21(39)7-10-42(31,6)41(18,5)14-13-37)56-35-30(26(48)25(47)29(58-35)33(52)53)59-34-27(49)23(45)24(46)28(57-34)32(50)51/h15,19,21-31,34-35,43,45-49H,7-14,16-17H2,1-6H3,(H,50,51)(H,52,53)(H,54,55)/t19-,21+,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35+,37+,38-,39-,40+,41+,42+/m0/s1
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| Chemical Name |
(2S,3S,4S,5R,6R)-6-[(2R,3R,4S,5S,6S)-2-[[(3S,4S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4-(hydroxymethyl)-4,6a,6b,8a,11,14b-hexamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
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| Synonyms |
Saponin G2, from licorice; Licorice-saponin G2; Licoricesaponin G2
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~119.20 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (2.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (2.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1920 mL | 5.9599 mL | 11.9198 mL | |
| 5 mM | 0.2384 mL | 1.1920 mL | 2.3840 mL | |
| 10 mM | 0.1192 mL | 0.5960 mL | 1.1920 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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