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    Licochalcone A
    Licochalcone A

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1729
    CAS #: 58749-22-7Purity ≥98%

    Description: Licochalcone A is a naturally occuring and estrogenic chalcone compound extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis.

    References: Antimicrob Agents Chemother. 1993 Dec;37(12):2550-6; Antimicrob Agents Chemother. 1994 Jun;38(6):1339-44.

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    Molecular Weight (MW)338.4
    FormulaC21H22O4
    CAS No.58749-22-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 67 mg/mL (198.0 mM)
    Water: <1 mg/mL
    Ethanol: 67 mg/mL (198.0 mM)
    Other info

    Chemical Name: (E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

    InChi Key: KAZSKMJFUPEHHW-DHZHZOJOSA-N

    InChi Code: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+

    SMILES Code: O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC

    Synonyms

    Licochalcone-A


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    In Vitro

    In vitro activity: Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis.


    Cell Assay: The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 µL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.

    In VivoIn mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity.
    Animal modelMice infected with L. major
    Formulation & DosageDissolved in 20 uL of 99% (v/v) ethanol and suspended in 1% carboxymethyl cellulose (CMC) solution; 5mg/kg; Oral gavage or i.p. injection
    References

    Antimicrob Agents Chemother. 1993 Dec;37(12):2550-6; Antimicrob Agents Chemother. 1994 Jun;38(6):1339-44.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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