| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 100mg | |||
| Other Sizes |
| ln Vitro |
Two kinds of opioid peptides that are present in the spinal cord's dorsal horn include dynorphin and enkephalins, which include met-enkephalin, leucine-enkephalin, and enkephalin-8. There are three primary subtypes of opioid receptors: mu, delta, and kappa. Potential endogenous ligands for delta and kappa opioid receptors are enkephalin and dynorphin, respectively. Three receptor types that resemble the delta and kappa opioid receptors seen in vertebrates have been identified by autoradiography and pharmacologically described in brain tissue (e.g., Ki=18.9 nM for leucine enkephalin). C's CHH terminal. maenas SG [1]. The mammalian brain naturally contains a pentapeptide called leucine-enkephalin, which has characteristics similar to morphine [2].
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|---|---|
| References | |
| Additional Infomation |
Leucine enkephalin is a pentapeptide composed of L-tyrosine, glycine, L-phenylalanine, and L-leucine residues linked by peptide bonds. It is an endogenous opioid peptide found in vertebrates, including rodents, primates, and humans, produced from the breakdown of proenkephalin or dynorphin, and possesses analgesic properties. It functions as a delta-opioid receptor agonist, a muon-opioid receptor agonist, a neurotransmitter, and an analgesic, and is also a metabolite in humans and rodents. Its function is related to L-tyrosine, glycine, L-phenylalanine, and L-leucine. It is a zwitterion of leucine enkephalin. The YGGFL zwitterion has been reported in mussels (Mytilus edulis), and relevant data are available. It is one of the endogenous pentapeptides with morphine-like activity. It differs from methionine enkephalin in that its fifth amino acid is leucine. Its first four amino acid sequences are identical to the N-terminal tetrapeptide sequence of β-endorphin.
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| Molecular Formula |
C28H37N5O7
|
|---|---|
| Molecular Weight |
555.6227
|
| Exact Mass |
555.269
|
| CAS # |
58822-25-6
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| PubChem CID |
461776
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.274 g/cm3
|
| Boiling Point |
998.8ºC at 760 mmHg
|
| Flash Point |
557.8ºC
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| Index of Refraction |
1.586
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| LogP |
2.101
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| Hydrogen Bond Donor Count |
7
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
40
|
| Complexity |
854
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
|
| InChi Key |
URLZCHNOLZSCCA-VABKMULXSA-N
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| InChi Code |
InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1
|
| Chemical Name |
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 150 mg/mL (~269.97 mM)
H2O : ~100 mg/mL (~179.98 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 6.67 mg/mL (12.00 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7998 mL | 8.9990 mL | 17.9979 mL | |
| 5 mM | 0.3600 mL | 1.7998 mL | 3.5996 mL | |
| 10 mM | 0.1800 mL | 0.8999 mL | 1.7998 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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