| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
From 100 μM onward, L-NMMA generated concentration-dependent suppression (2Hz) of induced relaxation; the average maximal inhibition at 1 mM was about 35%. When L-arginine (L-Arg) was previously incubated with D-arginine, the inhibitory action of L-NMMA remained unaltered. The relaxation brought on by isoproterenol is unaffected by L-NMMA [2]. L-NMMA infusion decreased arteriolar diameter and increased arteriolar tone in a dose-dependent manner. L-NMMA functions quite instantly. When it comes to the endothelium-dependent vasodilator ACh, but not the endothelium-independent NP, L-NMMA reduces the vasodilatory response. L-NMMA dramatically increases the dose-related vasoconstriction that NE produces [3].
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|---|---|
| References |
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| Molecular Formula |
C9H20N4O4
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|---|---|
| Molecular Weight |
248.28
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| Exact Mass |
248.148
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| CAS # |
53308-83-1
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| PubChem CID |
135242
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| Appearance |
White to off-white solid powder
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| Boiling Point |
392.7ºC at 760 mmHg
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| Melting Point |
180-190ºC
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| Flash Point |
191.3ºC
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| LogP |
0.595
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
17
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| Complexity |
224
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N
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| InChi Key |
IKPNWIGTWUZCKM-JEDNCBNOSA-N
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| InChi Code |
InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
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| Chemical Name |
acetic acid;(2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid
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| Synonyms |
LNMMA acetate; L NMMA acetate; L-NMMA acetate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~201.39 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (402.77 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0277 mL | 20.1386 mL | 40.2771 mL | |
| 5 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL | |
| 10 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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