| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
L-Fucose is a natural monosaccharide and does not have a specific pharmacological target. It is a component of glycans and glycolipids on cell surfaces. L-Fucose is involved in various biological processes including cell-cell recognition, immune responses, and development. It is also a component of human milk oligosaccharides and is one of the eight essential sugars in the human body. The compound is used as a substrate for enzyme assays.
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| ln Vitro |
In vitro, L-Fucose is used as a substrate to identify, differentiate, and characterize enzymes including fucosidase(s), L-fucose isomerase(s), and L-fucose dehydrogenase(s). It is also used in research on glycan-containing polysaccharides and as a glycan-modifying carbohydrate that produces antigenic sites recognized by IgE antibodies. The compound is involved in the degradation of plant and algal cell wall sugars.
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| ln Vivo |
In vivo, L-Fucose is a naturally occurring sugar found in the human body and in various foods. It is a component of glycoproteins and glycolipids on cell surfaces. L-Fucose is involved in immune recognition and inflammatory processes. It is claimed to have applications in cosmetics, pharmaceuticals, and dietary supplements. The compound is also a component of human milk.
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| Enzyme Assay |
In vitro enzyme assays using L-Fucose measure the activity of fucosidases, fucose isomerases, and fucose dehydrogenases. The enzyme is incubated with L-Fucose substrate, and the reaction product is quantified by spectrophotometric, fluorometric, or chromatographic methods. For fucosidase assays, the release of fucose from a fucosylated substrate is measured. For fucose dehydrogenase, the reduction of NAD+ or NADP+ is monitored.
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| Cell Assay |
In vitro cell-based assays using L-Fucose assess its effects on cell surface glycosylation and immune recognition. Cells are cultured in media containing L-Fucose, and changes in glycan composition are analyzed by lectin binding or mass spectrometry. The compound's effects on cell signaling, adhesion, and immune responses may also be evaluated. L-Fucose is also used in studies of glycan metabolism.
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| Animal Protocol |
In vivo animal studies using L-Fucose investigate its effects on immune function, inflammation, and development. The compound is administered orally or by injection, and its effects on glycan composition, immune responses, and disease outcomes are evaluated. L-Fucose has been studied in models of allergic inflammation, cancer, and infectious diseases. Its role in human milk oligosaccharides and infant development is also of interest.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of L-Fucose have been characterized in research studies. As a monosaccharide, it is absorbed from the gastrointestinal tract and distributed to tissues. L-Fucose is metabolized through the L-fucose pathway, involving conversion to L-fuculose and then to L-fuculose-1-phosphate. It is incorporated into glycans on cell surfaces. The compound is excreted primarily via urine.
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| Toxicity/Toxicokinetics |
L-Fucose has low toxicity and is generally recognized as safe for consumption. It is a naturally occurring sugar found in the human body and in various foods. High doses may cause gastrointestinal discomfort. The compound is not known to be genotoxic or carcinogenic. It is used as a dietary supplement and in cosmetic formulations.
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| Additional Infomation |
Aldehyde-L-fucose is an L-fucose, and also an aldehyde-fucose. It is the enantiomer of aldehyde-D-fucose. (2S,3R,4R,5S)-2,3,4,5-tetrahydroxyhexanal has been reported in alfalfa (Medicago sativa), Ascoseira mirabilis, and other organisms with relevant data. It is a six-membered ring deoxysugar with the chemical formula C6H12O5. Its molecule lacks a hydroxyl group at the 6-carbon position. See also: L-fucose (note moved here).
L-Fucose is a naturally occurring monosaccharide found on glycans and glycolipids on cell surfaces. It is one of the eight essential sugars in the human body. L-Fucose has applications in cosmetics, pharmaceuticals, and dietary supplements. It is used as a research tool for studying glycans, glycosylation, and immune function. The compound is also a component of human milk oligosaccharides. |
| Molecular Formula |
C6H12O5
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|---|---|
| Molecular Weight |
164.15
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| Exact Mass |
164.068
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| CAS # |
2438-80-4
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| PubChem CID |
3034656
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
399.1±35.0 °C at 760 mmHg
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| Melting Point |
150-153 °C(lit.)
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| Flash Point |
209.3±22.4 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
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| Index of Refraction |
1.531
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| LogP |
-2.04
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
11
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| Complexity |
126
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O([H])[C@]([H])([C@]([H])(C([H])([H])[H])O[H])[C@]([H])([C@@]([H])(C([H])=O)O[H])O[H]
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| InChi Key |
PNNNRSAQSRJVSB-KCDKBNATSA-N
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| InChi Code |
InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h2-6,8-11H,1H3/t3-,4+,5+,6-/m0/s1
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| Chemical Name |
(2S,3R,4R,5S)-2,3,4,5-tetrahydroxyhexanal
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| Synonyms |
Fucosse; (-)-L-Fucose; L-Fucose
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~609.16 mM)
DMSO : ~50 mg/mL (~304.58 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (609.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0920 mL | 30.4599 mL | 60.9199 mL | |
| 5 mM | 1.2184 mL | 6.0920 mL | 12.1840 mL | |
| 10 mM | 0.6092 mL | 3.0460 mL | 6.0920 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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