| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
L-Aspartic acid, N-benzoyl-, does not have a specific therapeutic target. Its primary function is as a chemical reagent and synthetic intermediate. The benzoyl group serves as a protecting group for the amino functionality of aspartic acid, allowing for selective reactions at the carboxyl groups. In peptide synthesis, it is activated and coupled with other amino acids to form peptide bonds. Its in vitro and in vivo activity is not typically studied, as it is not intended for biological use.
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|---|---|
| ln Vitro |
It has been shown that N-benzoyl-L-aspartic acids produce internal anhydrides rather than oxazolones in aqueous acetic anhydride solutions, where they are resistant to racemization [2].
Detailed in vitro biological activity data for L-Aspartic acid, N-benzoyl- are not applicable, as it is a protected amino acid used primarily as a chemical reagent. Its utility is demonstrated in organic synthesis, where it is used to synthesize peptides and other compounds. Its purity and identity are confirmed using analytical techniques. |
| ln Vivo |
Detailed in vivo activity data for L-Aspartic acid, N-benzoyl- are not applicable, as the compound is not intended for biological use. It is a research chemical used in synthetic organic chemistry.
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| Enzyme Assay |
Non-cell-based assays for L-Aspartic acid, N-benzoyl- are not applicable, as it is not a drug. Its identity and purity are assessed using standard analytical chemistry techniques, including HPLC, NMR, and mass spectrometry.
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| Cell Assay |
Cellular assays for L-Aspartic acid, N-benzoyl- are not applicable, as it is not a drug. It is not used in cell-based studies.
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| Animal Protocol |
In vivo animal models for L-Aspartic acid, N-benzoyl- are not applicable, as it is not a drug. It is not used in animal studies.
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| ADME/Pharmacokinetics |
L-Aspartic acid, N-benzoyl- has a molecular weight of 237.21 g/mol and a molecular formula of C₁₁H₁₁NO₅. Its CAS number is 4631-12-3. The compound is a white to off-white crystalline solid. It is soluble in organic solvents such as DMSO and ethanol. Purity is typically ≥98%. Storage conditions: -20°C, protected from light and moisture.
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| Toxicity/Toxicokinetics |
L-Aspartic acid, N-benzoyl- is a protected amino acid with low toxicity. However, as a research chemical, standard laboratory safety precautions should be followed when handling it. It is for research use only and is not for human consumption.
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| References |
[1]. Friedrichs J, et, al. Novel glucosinolate metabolism in larvae of the leaf beetle Phaedon cochleariae. Insect Biochem Mol Biol. 2020 Sep;124:103431.
[2]. BARKER CC, et, al. The Dehydration and Racemisation of N-Acyl-L-aspartic Acids by Acetic Anhydride. Journal of the Chemical Society. 1953. |
| Additional Infomation |
L-Aspartic acid, N-benzoyl- is also known as N-Benzoyl-L-aspartic acid. It is a protected amino acid used as a building block in peptide synthesis. Its CAS number is 4631-12-3.
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| Molecular Formula |
C11H11NO5
|
|---|---|
| Molecular Weight |
237.21
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| Exact Mass |
237.064
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| CAS # |
4631-12-3
|
| PubChem CID |
205448
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| Appearance |
White to off-white solid powder
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| Density |
1.404g/cm3
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| Boiling Point |
502ºC at 760 mmHg
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| Flash Point |
257.4ºC
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| Index of Refraction |
1.588
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| LogP |
0.735
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
17
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| Complexity |
309
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(NC(C(O)=O)CC(O)=O)(=O)C1C=CC=CC=1
|
| InChi Key |
DJLTZJGULPLVOA-QMMMGPOBSA-N
|
| InChi Code |
InChI=1S/C11H11NO5/c13-9(14)6-8(11(16)17)12-10(15)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,12,15)(H,13,14)(H,16,17)/t8-/m0/s1
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| Chemical Name |
(2S)-2-benzamidobutanedioic acid
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| Synonyms |
L-N-Benzoylaspartic acid; L-Aspartic acid, N-benzoyl-
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1053.92 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (8.77 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (8.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2157 mL | 21.0784 mL | 42.1567 mL | |
| 5 mM | 0.8431 mL | 4.2157 mL | 8.4313 mL | |
| 10 mM | 0.4216 mL | 2.1078 mL | 4.2157 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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