| Size | Price | |
|---|---|---|
| 250mg | ||
| Other Sizes |
| Targets |
L-Arabinitol does not have a specific pharmacological target but serves as a metabolite and a biomarker. It is a potential biomarker for the consumption of foods such as sweet potato, deerberry, and moth bean. It is associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency in humans. It is used as an inducer of xylanase expression in Hypocrea jecorina.
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|---|---|
| ln Vitro |
In vitro, L-Arabinitol is used as a rare sugar alcohol in research applications. It may be used as a sugar substitute due to its sweet taste and low caloric value. It is studied for its potential role in certain metabolic disorders.
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| ln Vivo |
L-Arabinitol is not administered as a therapeutic agent in vivo. Its utility is limited to in vitro and ex vivo applications as a research tool and biomarker.
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| Enzyme Assay |
In vitro assays for L-Arabinitol are typically analytical in nature. It can be quantified in biological samples by LC-MS/MS or GC-MS. It may be used as a standard in metabolomics studies. It is also used as an inducer of xylanase expression in fungal cultures.
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| Cell Assay |
Cellular assays for L-Arabinitol are not typically performed, as it is a metabolite rather than a pharmacological agent. It may be added to cell culture media as a nutrient or as a control in metabolic studies.
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| Animal Protocol |
L-Arabinitol is not used in in vivo animal studies as a therapeutic agent. It may be used in metabolic studies to trace the metabolism of arabinose or as a biomarker in dietary intervention studies.
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| ADME/Pharmacokinetics |
L-Arabinitol is a naturally occurring sugar alcohol and is metabolized through the pentose phosphate pathway. It is not administered as a drug.
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| Toxicity/Toxicokinetics |
L-Arabinitol is a naturally occurring sugar alcohol and is generally considered safe. No significant toxicity has been reported.
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| References | |
| Additional Infomation |
L-Arabatolitol is the L-enantiomer of arabinitol. It is a metabolite found in humans, Saccharomyces cerevisiae, and mice. It is the enantiomer of D-arabinitol. L-Arabatolitol is a metabolite found in or produced by Escherichia coli (strains K12 and MG1655). L-Arabatolitol has also been reported in Adonis vernalis, with relevant data available. L-Arabatolitol is a metabolite found in or produced by Saccharomyces cerevisiae.
L-Arabinitol (L-(-)-Arabitol) is a naturally occurring sugar alcohol. It is a rare sugar alcohol being studied as a food additive. It is a potential biomarker for food consumption and is associated with Alzheimer's disease. It has a molecular weight of 152.15 and formula C5H12O5. It is not a drug. |
| Molecular Formula |
C5H12O5
|
|---|---|
| Molecular Weight |
152.1458
|
| Exact Mass |
152.068
|
| CAS # |
7643-75-6
|
| PubChem CID |
439255
|
| Appearance |
White to off-white solid powder
|
| Density |
1.5±0.1 g/cm3
|
| Boiling Point |
494.5±40.0 °C at 760 mmHg
|
| Melting Point |
101-104ºC(lit.)
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| Flash Point |
261.9±21.9 °C
|
| Vapour Pressure |
0.0±2.9 mmHg at 25°C
|
| Index of Refraction |
1.571
|
| LogP |
-3.77
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
10
|
| Complexity |
76.1
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
C([C@@H](C([C@H](CO)O)O)O)O
|
| InChi Key |
HEBKCHPVOIAQTA-IMJSIDKUSA-N
|
| InChi Code |
InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1
|
| Chemical Name |
(2S,4S)-pentane-1,2,3,4,5-pentol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~657.25 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.5725 mL | 32.8623 mL | 65.7246 mL | |
| 5 mM | 1.3145 mL | 6.5725 mL | 13.1449 mL | |
| 10 mM | 0.6572 mL | 3.2862 mL | 6.5725 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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