| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
In protein fragment complementation tests, KJ Pyr 9 (KJ-Pyr-9) induces disruptions in the MYC-MAX complex in cells [1]. KJ Pyr 9 had little influence on the food activity of a few unrelated oncoproteins and only mild effects on MYC-induced inducible transformation in suspension in cells [1]. MYC-overexpressing human and avian cell proliferation is preferentially inhibited by KJ Pyr 9, which also dramatically lowers the MYC-driven opsonic signature [1]. Increased MYC activity is required for KJ Pyr 9's recognized effects on the clear cell lines NCI-H460, MDA-MB-231, and SUM-159PT [1]. All cell lines having IC50 values between 5 and 10 μM are included in KJpyr 9. Burkitt cell lines with constitutively high c-MYC expression (IC50 values between 1 and 2.5 μM) are more sensitive to KJ Pyr 9 proliferation [1].
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|---|---|
| ln Vivo |
Growth inhibition is a property of KJ Pyr 9 (intraperitoneal injection; 10 mg/kg; once day for 31 tumor days) [1].
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| References |
| Molecular Formula |
C22H15N3O4
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|---|---|
| Molecular Weight |
385.379
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| Exact Mass |
385.106
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| CAS # |
581073-80-5
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| PubChem CID |
85855478
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
584.4±50.0 °C at 760 mmHg
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| Flash Point |
307.2±30.1 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.646
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| LogP |
4.48
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
29
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| Complexity |
579
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
GTTDVYCKFQYVNN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)
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| Chemical Name |
4-[2-(furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl]benzamide
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| Synonyms |
KJ Pyr-9; KJPyr-9; KJ-Pyr-9
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~324.36 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (6.49 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 2.08 mg/mL (5.40 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5948 mL | 12.9742 mL | 25.9484 mL | |
| 5 mM | 0.5190 mL | 2.5948 mL | 5.1897 mL | |
| 10 mM | 0.2595 mL | 1.2974 mL | 2.5948 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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