| Size | Price | Stock | Qty |
|---|---|---|---|
| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| Targets |
influenza virus(IC50= 2 μM);DNV(IC50>5 μM)
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| ln Vitro |
Significant reduction in the abundance of NP protein is observed when exposed to KIN 101 (10 μM) for 24 hours.The HCV RNA levels in KIN 101 (10 μM; 18 hours) decrease by more than one log[1].
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has an IC50 of 0.2 μM and significantly and dose-dependently affects the formation of foci.In MRC5 cells, KIN 101 (5, 10, 20, 50 μM; 4 hours) reduces influenza virus infection in a dose-dependent manner.ISG levels, as well as those of other proteins like RIG-I and MDA5 that are activated downstream of IRF, are significantly elevated by KIN 101[1].
The antiviral activity of KIN101 (0.1-100 μM; 18 hours) is demonstrated against the hepatitis C virus (HCV)[2]. |
| References |
| Molecular Formula |
C16H11BRO5S
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|---|---|
| Molecular Weight |
395.22
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| Exact Mass |
393.95
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| Elemental Analysis |
C, 48.62; H, 2.81; Br, 20.22; O, 20.24; S, 8.11
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| CAS # |
610753-87-2
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| SMILES |
O=C1C(C2=CC=C(C=C2)Br)=COC3=CC(OS(=O)(C)=O)=CC=C13
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| InChi Key |
SJGDYHHAYHRLNC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H11BrO5S/c1-23(19,20)22-12-6-7-13-15(8-12)21-9-14(16(13)18)10-2-4-11(17)5-3-10/h2-9H,1H3
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| Chemical Name |
3-(4-bromophenyl)-4-oxo-4H-chromen-7-yl methanesulfonate
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| Synonyms |
KIN101; KIN 101; KIN-101
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~41.67 mg/mL (~105.43 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5302 mL | 12.6512 mL | 25.3024 mL | |
| 5 mM | 0.5060 mL | 2.5302 mL | 5.0605 mL | |
| 10 mM | 0.2530 mL | 1.2651 mL | 2.5302 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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