| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Multiple targets have been identified for karanjin. It induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. It possesses antioxidant, anti-inflammatory, and gastroprotective properties. The compound also has larvicidal activity against Culex pipiens pallens and Aedes aegypti larvae.
|
|---|---|
| ln Vitro |
Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. It can induce cancer cell death through cell cycle arrest and enhance apoptosis. The compound possesses significant antioxidant, anti-inflammatory, and gastroprotective properties. Karanjin can significantly reverse diazepam-induced amnesia and improve learning and memory in mice. It has larvicidal activity against C. pipiens pallens and A. aegypti larvae.
|
| ln Vivo |
In vivo, karanjin has demonstrated gastroprotective properties. It can significantly reverse diazepam-induced amnesia and improve learning and memory in mice in a dose- and time-dependent manner. Karanjin may be effective clinically for cancer pharmacotherapy, as it can induce cancer cell death through cell cycle arrest and enhance apoptosis.
|
| Enzyme Assay |
In vitro enzyme assays for karanjin involve measuring its effects on AMPK activity or other enzymatic targets. AMPK activity is measured using appropriate substrates and various concentrations of karanjin. The compound induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity.
|
| Cell Assay |
In vitro cellular assays for karanjin involve treating cells (such as cancer cells, skeletal muscle cells, or neuronal cells) with the compound and measuring cell viability, apoptosis, GLUT4 translocation, or memory-related markers. Karanjin induces GLUT4 translocation in skeletal muscle cells and can induce cancer cell death through cell cycle arrest and enhance apoptosis.
|
| Animal Protocol |
In vivo animal studies for karanjin typically involve administration to rodent models to assess its gastroprotective, memory-enhancing, or anticancer effects. Karanjin can significantly reverse diazepam-induced amnesia and improve learning and memory in mice. It has gastroprotective properties and may be effective for cancer pharmacotherapy.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for karanjin is limited. The compound has a molecular weight of 292.29 and a molecular formula of C18H12O4. It is a furanoflavonol with diverse biological activities. Further pharmacokinetic studies are needed to support its development as a therapeutic agent.
|
| Toxicity/Toxicokinetics |
Preclinical toxicity studies of karanjin are limited. The compound possesses antioxidant, anti-inflammatory, and gastroprotective properties, suggesting a favorable safety profile. It can induce cancer cell death through cell cycle arrest and enhance apoptosis. Comprehensive toxicological evaluation is needed before clinical development.
|
| References |
: Bose M, Chakraborty M, Bhattacharya S, Mukherjee D, Mandal S, Mishra R. Prevention of arthritis markers in experimental animal and inflammation signalling in macrophage by Karanjin isolated from Pongamia pinnata seed extract. Phytother Res. 2014 Aug;28(8):1188-95. doi: 10.1002/ptr.5113. Epub 2014 Jan 7. PubMed PMID: 24399783.
|
| Additional Infomation |
Karanjin is an extended flavonoid compound. It has been reported to exist in Millettia pulchra, Fordia cauliflora, and other organisms with relevant data.
Karanjin is a major active furanoflavonol constituent from Pongamia pinnata and Fordia cauliflora with diverse biological activities including antioxidant, anti-inflammatory, gastroprotective, antimicrobial, antitumor, and insecticidal properties. It induces GLUT4 translocation by increasing AMPK activity, induces cancer cell death through cell cycle arrest and apoptosis, and reverses diazepam-induced amnesia in mice. |
| Molecular Formula |
C18H12O4
|
|---|---|
| Molecular Weight |
292.2855
|
| Exact Mass |
292.073
|
| CAS # |
521-88-0
|
| PubChem CID |
100633
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
463.0±45.0 °C at 760 mmHg
|
| Melting Point |
156ºC
|
| Flash Point |
233.8±28.7 °C
|
| Vapour Pressure |
0.0±1.1 mmHg at 25°C
|
| Index of Refraction |
1.678
|
| LogP |
3.29
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
22
|
| Complexity |
478
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
LKPQNZRGGNOPPU-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
|
| Chemical Name |
3-Methoxy-2-phenyl-4H-furo(2,3-h)(1)benzopyran-4-one
|
| Synonyms |
NSC335755 NSC-335755 NSC 335755
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~114.03 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4213 mL | 17.1063 mL | 34.2126 mL | |
| 5 mM | 0.6843 mL | 3.4213 mL | 6.8425 mL | |
| 10 mM | 0.3421 mL | 1.7106 mL | 3.4213 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA