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    Onametostat (JNJ-64619178)
    Onametostat (JNJ-64619178)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4503
    CAS #: 2086772-26-9Purity ≥98%

    Description: Onametostat (JNJ-64619178; JNJ64619178) is a novel, potent, selective and pseudo-irreversible PRMT5 (protein arginine methyltransferase 5) inhibitor with potential anticancer activity. It inhibits PRMT5 with an IC50 of 0.14 nM. As an important epigenetics related enzyme, protein arginine methyltransferase 5 (PRMT5) has been confirmed as an anticancer therapeutic target in recent years. Among all the reported PRMT5 inhibitors, two small molecules (GSK-3326595 and JNJ-64619178) are currently being assessed in clinical trial. 

    References: Chem Pharm Bull (Tokyo). 2019;67(4):382-388. 


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    JNJ-64619178

    Name: JNJ-64619178
    CAS#: 2086772-26-9
    Chemical Formula: C22H23BrN6O2
    Exact Mass: 482.1066
    Molecular Weight: 483.37
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: JNJ64619178; JNJ 64619178; JNJ-64619178.
    Chemical Name: (1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
    InChi Key: DBSMLQTUDJVICQ-CJODITQLSA-N
    InChi Code: InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
    SMILES Code: BrC1=C(N)N=C(C=C(CC[[email protected]@H]2[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1


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    Onametostat (JNJ-64619178; JNJ64619178) is a novel, potent, selective and pseudo-irreversible PRMT5 (protein arginine methyltransferase 5) inhibitor with potential anticancer activity. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.

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