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    JNJ-26854165 (Serdemetan)
    JNJ-26854165 (Serdemetan)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0013
    CAS #: 881202-45-5Purity ≥98%

    Description: Serdemetan (formerly JNJ26854165; JNJ-26854165; JNJ 26854165), originally developed as an activator of p53, is now considered to be a novel, potent and orally bioactive antagonist of Human Double Minute-2 (HDM-2) ubiquitin ligase with antitumor activities. It also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. 

    Reference: Pediatr Blood Cancer. 2012 Aug;59(2):329-32. 


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    Molecular Weight (MW)328.41
    FormulaC21H20N4
    CAS No.881202-45-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 66 mg/mL (200.96 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 2 mg/mL (6.08 mM)
    Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
    SynonymsJNJ26854165; JNJ-26854165; JNJ 26854165


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    GeneralJNJ 26854165 leads to significant differences in EFS distribution in 17 of the 36 (47%) evaluable solid tumor xenografts and in 5 of 7 (71%) of the evaluable ALL xenografts using a dose of 20 mg/kg administered via oral gavage daily for 5 days, repeated for 6 weeks
    Animal modelCB17SC scid female mice.
    FormulationDissolved in DMSO and then diluted in water.
    Dosages20 mg/kg
    AdministrationOral gavage
    Reference[1] Smith MA, et al. Pediatr Blood Cancer, 2012, 59(2), 329-332.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    JNJ-26854165 (Serdemetan)

     

    JNJ-26854165 (Serdemetan)



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