Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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Other Sizes |
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ln Vitro |
JMV 2959 is an IC50 of 32 nM growth fish rescue hormone 1a (GHS-R1a) restricted antagonist. JMV 2959 does not cause a calcium charge to occur inside cells [1].
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ln Vivo |
Furthermore, it does not significantly boost the release of growth hormone (GH) or enhance food intake [1]. JMV 2959 enhanced the percentage of prepulse inhibition (PPI) and dose-dependently decreased the startle reaction in the prepulse inhibition paradigm. The main cause of the modified startle response was the 27% decrease in startle that was seen at the maximum dosage of JMV 2959 (6 mg/kg) in comparison to the baseline drug [2]. Significant locomotor inhibition was generated by 6 mg/kg JMV 2959 on days 1 through 7, as compared to baseline day 0. Additionally, a significant interaction between JMV 2959 therapy and day was found in the results [3].
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References |
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Molecular Formula |
C30H32N6O2
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Molecular Weight |
508.614086151123
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Exact Mass |
508.258
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CAS # |
925238-89-7
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Related CAS # |
JMV 2959 hydrochloride;2448414-54-6
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PubChem CID |
16114404
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Appearance |
White to off-white solid powder
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LogP |
3.6
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Hydrogen Bond Donor Count |
3
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Hydrogen Bond Acceptor Count |
5
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Rotatable Bond Count |
11
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Heavy Atom Count |
38
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Complexity |
726
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Defined Atom Stereocenter Count |
1
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SMILES |
C(N[C@@H](C1N(CC2=CC=C(OC)C=C2)C(CCC2=CC=CC=C2)=NN=1)CC1C2=C(NC=1)C=CC=C2)(=O)CN
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InChi Key |
OZSZELOMMMKWTM-HHHXNRCGSA-N
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InChi Code |
InChI=1S/C30H32N6O2/c1-38-24-14-11-22(12-15-24)20-36-28(16-13-21-7-3-2-4-8-21)34-35-30(36)27(33-29(37)18-31)17-23-19-32-26-10-6-5-9-25(23)26/h2-12,14-15,19,27,32H,13,16-18,20,31H2,1H3,(H,33,37)/t27-/m1/s1
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Chemical Name |
2-amino-N-[(1R)-2-(1H-indol-3-yl)-1-[4-[(4-methoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]ethyl]acetamide
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Synonyms |
JMV-2959; JMV 2959; JMV2959
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~25 mg/mL (~49.15 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (9.83 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.09 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9661 mL | 9.8307 mL | 19.6614 mL | |
5 mM | 0.3932 mL | 1.9661 mL | 3.9323 mL | |
10 mM | 0.1966 mL | 0.9831 mL | 1.9661 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.