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| Other Sizes |
| Targets |
Jasmone does not have a specific pharmacological target. As a plant-derived natural product, its primary biological roles are as an insect attractant for pollinators or as a chemical cue for host location by insect herbivores. In plants, jasmone activates defense responses against insect attack and mechanical damage. The compound is not typically studied as a drug target but rather as a signaling molecule in plant-insect interactions and as a fragrance compound. It has potential biological activities such as antioxidant and antimicrobial properties.
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| ln Vitro |
In vitro, Jasmone has potential biological activities such as antioxidant and antimicrobial properties. As a plant-derived volatile compound, it may have effects on insect behavior and plant defense signaling. However, specific IC50 values or detailed pharmacological activity data is not provided in the available sources. The compound is primarily used as a fragrance and flavor ingredient rather than as a pharmacological agent.
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| ln Vivo |
In vivo, Jasmone acts as an insect chemical pheromone and plant defense agent. In plants, it is released as an attractant for pollinators or as a chemical cue for host location by insect herbivores. Jasmone plays an important role in plant defense activation in response to insect attack or mechanical damage. Its potential biological activities include antioxidant and antimicrobial properties. However, specific pharmacological efficacy data in animal models is not available.
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| Enzyme Assay |
No specific assay protocol is available for Jasmone. As a fragrance and plant signaling compound, it is not typically evaluated in receptor binding or enzyme inhibition assays. The compound may be analyzed by gas chromatography (GC) or gas chromatography-mass spectrometry (GC-MS) for quality control and purity assessment. For insect behavior studies, olfactometer assays or electroantennogram (EAG) recordings may be used.
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| Cell Assay |
No specific cell-based assay data is available for Jasmone. As a fragrance compound and plant signaling molecule, it is not typically used in pharmacological cell-based screening. The compound may be tested for antimicrobial activity using standard microbiological assays, but these are not standard pharmacological assays.
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| Animal Protocol |
No specific animal protocol is available for Jasmone. As a plant signaling compound, it is studied in plant-insect interaction models rather than animal models. For insect behavior studies, standard protocols involve olfactometer assays with various insect species. For safety assessments, standard toxicological studies for fragrance ingredients would apply.
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| ADME/Pharmacokinetics |
Jasmone has a molecular formula of C11H16O and a molecular weight of 164.24. The chemical name is 3-methyl-2-[(Z)-pent-2-enyl]cyclopent-2-en-1-one. It is a pale yellow, viscous liquid with a jasmine-like fragrance. The compound is commonly used in perfumery as a raw material for high-quality jasmine-based and floral perfumes. Comprehensive pharmacokinetic studies for therapeutic applications are not applicable.
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| Toxicity/Toxicokinetics |
Toxicity Summary
Identification and Uses: Jasmone is a pale yellow, viscous liquid (oil). It is commonly used in perfumery and is a raw material for high-quality jasmine-based and floral perfumes. Human Exposure and Toxicity: Jasmone did not cause skin sensitization in human volunteers. Animal Studies: In an acute skin toxicity study, 10 rabbits were given 5 g/kg of cis-jasmone and observed for 14 days. Nine animals developed severe erythema, and all animals developed moderate edema. Two rabbits developed eschar. Jasmone is non-irritating or non-sensitizing to guinea pigs. In a rabbit eye irritation study, the highest dose group showed significant erythema, increased secretions, and edema, which completely subsided by day 6. The remaining dose groups showed mild to moderate erythema and secretions, which completely subsided by day 3. Jasmone did not show mutagenicity in Ames plate incorporation assays and pre-incubation assays at concentrations up to 2500 μg/plate, regardless of metabolic activation. The Salmonella typhimurium strains used in the experiment were TA98, TA100, TA102, TA1535, and TA1537. However, in cytogenetic analysis of Chinese hamster ovary (CHO) cells, the frequency of sister chromatid exchange (SEC) was significantly increased at concentrations of 33.3 μM and 100 μM and 300 μM (maximum test dose). Non-human toxicity values Oral LD50 in rats: 5000 mg/kg Dermal LD50 in rats: >5 g/kg As a fragrance ingredient, Jasmone has been evaluated for safety in cosmetic applications. The compound is considered safe for use in perfumery at appropriate concentrations. However, comprehensive toxicological evaluation for therapeutic applications would be required. The compound is for research use only and not for therapeutic applications. |
| References | |
| Additional Infomation |
Jasmone is a cyclic ketone. It has been reported to be found in Malabar spinach, Malabar spinach, and other organisms with relevant data.
Jasmone is also known as cis-jasmone and has the PubChem CID 1549018 and CHEMBL ID CHEMBL2251602. It is an organic compound that is a volatile component of jasmine oil. Jasmone acts as an insect chemical pheromone and plant defense agent. It has potential antioxidant and antimicrobial properties. No drug development or clinical trial status applies. |
| Molecular Formula |
C11H16O
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|---|---|
| Molecular Weight |
164.24
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| Exact Mass |
164.12
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| CAS # |
488-10-8
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| PubChem CID |
1549018
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
264.2±0.0 °C at 760 mmHg
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| Melting Point |
203 - 205ºC
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| Flash Point |
107.2±0.0 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.491
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| LogP |
2.9
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
12
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| Complexity |
233
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC/C=C\CC1=C(C)CCC1=O
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| InChi Key |
XMLSXPIVAXONDL-PLNGDYQASA-N
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| InChi Code |
InChI=1S/C11H16O/c1-3-4-5-6-10-9(2)7-8-11(10)12/h4-5H,3,6-8H2,1-2H3/b5-4-
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| Chemical Name |
3-methyl-2-[(Z)-pent-2-enyl]cyclopent-2-en-1-one
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| Synonyms |
BRN 1907713; (Z)-Jasmone; Jasmone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~608.87 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0887 mL | 30.4433 mL | 60.8865 mL | |
| 5 mM | 1.2177 mL | 6.0887 mL | 12.1773 mL | |
| 10 mM | 0.6089 mL | 3.0443 mL | 6.0887 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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