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Itacitinib adipate (INCB 39110 adipate)

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InvivoChem Cat #: V0066

CAS #: 1334302-63-4Purity ≥98%

Description: Itacitinib adipate, the adipate salt of itacitinib which is also known as INCB39110, is a potent, selective and orally bioavailable inhibitor of JAK1 (Janus-associated kinase 1) with potential antineoplastic activity, currently in Phase II clinical trials for the treatment of myelofibrosis, rheumatoid arthritis and plaque psoriasis.

References: Haematologica. 2017 Feb;102(2):327-335; Expert Opin Ther Pat. 2017 Feb;27(2):127-143; AACR; Cancer Res. 2015, 75(15 Suppl).

Related CAS: 1334298-90-6 (free base) 1334302-63-4 (adipate salt)

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Molecular Weight (MW)	699.66
Formula	C₃₂H₃₃F₄N₉O₅
CAS No.	1334302-63-4 (adipate salt)
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: >90 mg/mL
	Water: N/A
	Ethanol: >90 mg/mL
Chemical Name	2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile adipate
Synonyms	INCB039110; INCB-039110; INCB 039110; INCB39110; INCB 39110; INCB-39110
SMILES Code	N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1 .O=C(O)CCCCC(O)=O

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In Vitro	In vitro activity: Itacitinib (also known as INCB39110) is a potent, selective and orally bioavailable inhibitor of JAK1 (Janus-associated kinase 1) with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2 (IC50 for JAK1, 2, 3, and TYK2 are 2, 63, >2000, and 795 nM, respectively). It has potential antineoplastic activity and is currently in Phase II clinical trials for the treatment of myelofibrosis, rheumatoid arthritis and plaque psoriasis. Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2) that are critical in cytokine signalling and are strongly linked to both cancer and inflammatory diseases. Kinase Assay: Itacitinib has >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2 (IC50 for JAK1, 2, 3, and TYK2 are 2, 63, >2000, and 795 nM, respectively).
In Vivo	Itacitinib is able to inhibit tumor growth in human pancreatic xenograft models in mice at clinically relevant doses, both as monotherapy and in combination with cytotoxic agents such as gemcitabine.
Animal model	Human pancreatic xenograft models in mice
Formulation & Dosage	N/A
References	Haematologica. 2017 Feb;102(2):327-335; Expert Opin Ther Pat. 2017 Feb;27(2):127-143; AACR; Cancer Res. 2015, 75(15 Suppl).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%

Itacitinib adipate

Treatment effects on total symptom score (TSS). Haematologica. 2017 Feb;102(2):327-335

Itacitinib adipate

Treatment effects on spleen volume. Haematologica. 2017 Feb;102(2):327-335.

Itacitinib adipate

Mean hemoglobin level and platelet count over time by dose cohort. Haematologica. 2017 Feb;102(2):327-335.

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