| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
The primary target of Ipfencarbazone is the biosynthesis of very long-chain fatty acids (VLCFAs) in plants. By inhibiting VLCFA elongation, it disrupts the formation of important plant cell membrane components, leading to growth inhibition and death of susceptible weeds, particularly in rice paddies.
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|---|---|
| ln Vitro |
In vitro, Ipfencarbazone inhibits VLCFA elongation in plant enzyme assays. Its herbicidal activity is assessed by measuring its effect on the growth of target weed species in controlled environments. It is used as a herbicide to control weeds like aquatic weeds in rice.
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| ln Vivo |
In vivo, Ipfencarbazone is applied as a herbicide in agricultural settings. It provides effective control of weeds in rice fields. Its efficacy and crop safety have been established in field trials. It is a valuable tool for weed management in rice cultivation.
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| Enzyme Assay |
For herbicidal activity assays, Ipfencarbazone is applied to target weed species at various concentrations. Plant growth (e.g., height, biomass) is measured, and the dose-response relationship is determined. For enzyme assays, VLCFA elongase activity is measured in plant microsomes using radiolabeled substrates.
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| Cell Assay |
For cellular studies in plants, cell suspension cultures or protoplasts are treated with Ipfencarbazone. VLCFA synthesis is measured by incorporating radiolabeled precursors. Cell viability and membrane integrity are assessed.
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| Animal Protocol |
For in vivo efficacy studies, Ipfencarbazone is applied as a pre-emergence or post-emergence treatment in rice paddies. Weed control efficacy is assessed by counting weed density and measuring weed biomass. Crop safety is evaluated by monitoring rice growth and yield.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Ipfencarbazone are not applicable, as it is a herbicide. Its uptake, translocation, and metabolism in plants and its environmental fate are relevant for its efficacy and safety.
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| Toxicity/Toxicokinetics |
Toxicological data for Ipfencarbazone indicate that it is of low toxicity to mammals, with a rat acute oral LD50 > 2000 mg/kg. It may cause some eye and skin irritation but is not a sensitizer. As with all chemicals, appropriate safety precautions should be taken during handling.
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| Additional Infomation |
Ipfencarbazone (CAS 212201-70-2) is a triazolinone herbicide used in rice. It inhibits VLCFA elongation. It has the molecular formula C₁₈H₁₄Cl₂F₂N₄O₂ and a molecular weight of 427.23. It is of low toxicity to mammals and is strictly for research use.
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| Molecular Formula |
C18H14N4O2F2CL2
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|---|---|
| Molecular Weight |
427.23216
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| Exact Mass |
426.046
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| CAS # |
212201-70-2
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| PubChem CID |
15457339
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| Appearance |
White to off-white solid powder
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| Density |
1.46g/cm3
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| Boiling Point |
494.5ºC at 760 mmHg
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| Flash Point |
252.8ºC
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| Index of Refraction |
1.626
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| LogP |
4.502
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
28
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| Complexity |
639
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
DHYXNIKICPUXJI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H14Cl2F2N4O2/c1-10(2)25(16-6-4-12(21)8-14(16)22)17(27)24-9-23-26(18(24)28)15-5-3-11(19)7-13(15)20/h3-10H,1-2H3
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| Chemical Name |
1-(2,4-dichlorophenyl)-N-(2,4-difluorophenyl)-5-oxo-N-propan-2-yl-1,2,4-triazole-4-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~130 mg/mL (~304.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.17 mg/mL (5.08 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.17 mg/mL (5.08 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3407 mL | 11.7033 mL | 23.4066 mL | |
| 5 mM | 0.4681 mL | 2.3407 mL | 4.6813 mL | |
| 10 mM | 0.2341 mL | 1.1703 mL | 2.3407 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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