| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
Complete prevention of cell death induced by tert-butyl hydroperoxide (tBH) was similarly achieved by preincubation with Imeglimin (10 mM, 4 h or 100 μM, 24 h) [2].
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| ln Vivo |
During the final six weeks of HFHSD feeding, meglimin (200 mg/kg b.i.d. orally) dramatically lowers hyperglycemia and returns normal glucose tolerance [1].
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| Cell Assay |
Cell Viability Assay [2]
Cell Types: Human Endothelial Cells (HMEC-1) Tested Concentrations: 100 μM and 10 mM Incubation Duration: 100 μM 24 hrs (hours), 10 mM 4 hrs (hours) Experimental Results: Prevents cell death. |
| Animal Protocol |
Animal/Disease Models: Male C57BL/6JOlaHsd mice (4 weeks old) [1]
Doses: 200 mg/kg Route of Administration: po (oral gavage); bid; 6 weeks Experimental Results: A slight decrease in body weight and food intake was observed, and There is some diarrhea, but only during the first few days of treatment. |
| References |
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| Molecular Formula |
C6H14CLN5
|
|---|---|
| Molecular Weight |
191.6619
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| Exact Mass |
191.093
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| CAS # |
775351-61-6
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| Related CAS # |
Imeglimin;775351-65-0
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| PubChem CID |
54763513
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
205
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| Defined Atom Stereocenter Count |
1
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| SMILES |
Cl[H].N(C([H])([H])[H])(C([H])([H])[H])C1=N[C@]([H])(C([H])([H])[H])N=C(N([H])[H])N1[H]
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| InChi Key |
UXHLCYMTNMEXKZ-PGMHMLKASA-N
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| InChi Code |
InChI=1S/C6H13N5.ClH/c1-4-8-5(7)10-6(9-4)11(2)3;/h4H,1-3H3,(H3,7,8,9,10);1H/t4-;/m1./s1
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| Chemical Name |
(4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine;hydrochloride
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| Synonyms |
Imeglimin HCl EMD387008 hydrochlorideImeglimin hydrochloride EMD387008 HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~260.88 mM)
DMSO : ~25 mg/mL (~130.44 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.85 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.85 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.85 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (521.76 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2176 mL | 26.0879 mL | 52.1757 mL | |
| 5 mM | 1.0435 mL | 5.2176 mL | 10.4351 mL | |
| 10 mM | 0.5218 mL | 2.6088 mL | 5.2176 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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