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    Ifenprodil Tartrate
    Ifenprodil Tartrate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1093
    CAS #: 23210-58-4Purity ≥98%

    Description: Ifenprodill Tartrate (RC61-91; RC6191; RC6191; RC-6191), the tartrate salt of Ifenprodill, is a potent and atypical noncompetitive antagonist at the NMDA/N-methyl-D-aspartate receptor with a wide variety of activities such as central nervous system (CNS) stimulating, anti-inflammatory, neuroprotective, and anti-fibrotic effects. 

    References: Mol Pharmacol. 1993 Oct;44(4):851-9; J Neurosci. 1998 Mar 15;18(6):1935-43.

    Related CAS #: 23210-58-4 (tartrate); 23210-56-2 (free base); 66157-43-5 (tartrate); 66516-92-5 (Ifenprodil glucuronide)

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    Molecular Weight (MW)800.98
    FormulaC21H27NO2.1/2C4H6O6
    CAS No.23210-58-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 95 mg/mL (118.6 mM)
    Water: 9 mg/mL (11.23 mM)
    Ethanol: 62 mg/mL (77.4 mM)
    Other info

    Chemical Name: 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol; (2R,3R)-2,3-dihydroxysuccinate (2:1)

    InChi Key: DMPRDSPPYMZQBT-CEAXSRTFSA-N

    InChi Code: InChI=1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

    SMILES: OC1=CC=C(C(O)C(N2CCC(CC3=CC=CC=C3)CC2)C)C=C1.OC4=CC=C(C(O)C(N5CCC(CC6=CC=CC=C6)CC5)C)C=C4.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O

    Synonyms

    RC 61-91; RC 6191; Ifenprodil; RC-61-91; RC61-91;  Ifenprodil hemitartrate; RC61-91; RC6191; Ifenprodil tartrate; 


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    In Vitro

    In vitro activity: Ifenprodil inhibits NMDA-induced currents at NR1A/NR2B and NR1A/NR2A receptors with IC50 of 0.34 μM and 146 μM in oocytes voltage-clamped at -70 mV. Ifenprodil may act as a weak open-channel blocker of NR1A/NR2A receptors, the degree of inhibition seen with 100 μM Ifenprodil at NR1A/NR2A receptors is not altered by changes in the concentration of extracellular glycine. The inhibitory effect of 1 mM Ifenprodil at NR1A/NR2B receptors is reduced by increasing the concentration of glycine. Ifenprodil (10 μM) inhibits virtually all of the NMDA receptor-evoked current in very young rat cortical neurons that contain a single population of receptors exhibiting a high affinity for glycine. Ifenprodil (10 μM) inhibits both the high-affinity population and a significant proportion of the low-affinity component in older rat cortical neurons, thus revealing three pharmacologically distinct populations of NMDA receptors in single neurons. Ifenprodil antagonizes NMDA receptors in an activity-dependent manner, whilst also increasing the receptor affinity for glutamate recognition-site agonists. Ifenprodil inhibition curves against 10 μM and 100 μM NMDA-evoked currents yielded IC50 values of 0.88 μM and 0.17 μM, respectively. Ifenprodil (3 μM) potentiates to approximately 200% of control levels in rat cultured cortical neurones. Ifenprodil exhibits a 39- and 50-fold higher affinity for the agonist-bound activated and desensitized states of the NMDA receptor, respectively, relative to the resting, agonist-unbound state. Ifenprodil binding to the NMDA receptor results in a 6-fold higher affinity for glutamate site agonists.

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    References

    Mol Pharmacol. 1993 Oct;44(4):851-9; J Neurosci. 1998 Mar 15;18(6):1935-43.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Ifenprodil Tartrate

    Biphasic ifenprodil inhibition curves from 27- to 29-d-old cortical neurons. J Neurosci.1998 Mar 15;18(6):1935-43.
     

    Ifenprodil Tartrate

    Fast application of 7chlorokynurenic acid during a 100 μm glutamate- plus 30 μm glycine-evoked steady-state current reveals high- and low-affinity glycine components. J Neurosci. 1998 Mar 15;18(6):1935-43.


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