| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
By reducing the generation of reactive oxygen species (ROS) brought on by angiotensin II, idoxifene protects vascular smooth muscle cells. Idoxifene causes culture-activated HSC death in a time-dependent manner, reduces HSC activation considerably, and decreases culture-activated HSC growth in a dose-dependent manner [1]. Idoxifene exhibits very little agonist action in human endometrial cells but functions as an estrogen agonist for osteoblasts in bone. By preventing the activation of the pro-inflammatory transcription factor NF-κB, idoxifene and E2 shield hepatocytes from damage caused by inflammatory cells [2].
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|---|---|
| ln Vivo |
Animals were given daily intraperitoneal injections of estradiol (0.5 mg/kg) and oral administration of edoxifen (0.02, 0.1, and 0.5 mg/kg) three days following dimethylnitrosamine (DMN) therapy. LDH and estradiol (E2) levels in the blood as well as the histological grade of liver zone 3 necrosis (score 0 to 5) were measured. Idedoxifene dramatically decreased liver collagen and MDA levels in the DMN model in a dose-dependent manner at dosages more than 0.1 mg/kg. Even though edoxifen and E2 are administered by oral and intraperitoneal injection, respectively, their anti-fibrotic effects are marginally greater at 0.5 mg/kg of edoxifen than they are at the same dose of E2 [2].
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| References | |
| Additional Infomation |
Idoxifene is a stilbenoid.
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| Molecular Formula |
C28H30NOI
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|---|---|
| Molecular Weight |
523.4479
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| Exact Mass |
523.137
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| CAS # |
116057-75-1
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| PubChem CID |
3034011
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
573.4±50.0 °C at 760 mmHg
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| Melting Point |
108-109° (McCague et al.)
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| Flash Point |
300.6±30.1 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.623
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| LogP |
9.5
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
31
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| Complexity |
547
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| Defined Atom Stereocenter Count |
0
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~95.52 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (9.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9104 mL | 9.5520 mL | 19.1040 mL | |
| 5 mM | 0.3821 mL | 1.9104 mL | 3.8208 mL | |
| 10 mM | 0.1910 mL | 0.9552 mL | 1.9104 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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