| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
Hypoxanthine has the ability to produce free radicals. Hypoxanthine is involved in the pathophysiology of numerous disorders because it seems to contribute to the formation of oxygen free radicals that cause harm to reoxygenated cells following hypoxia. Because it inhibits phosphodiesterases in the brain and interacts with benzodiazepine receptors, hypoxanthine also controls a wide range of other physiological functions. The effectiveness of several cytotoxic medications may be impacted by hypoxanthine's inhibition of their effects [1].
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|---|---|
| ln Vivo |
It was discovered that the amount of hypoxanthine in pig plasma increased linearly with the length of hypoxemia, with no distinction between venous and arterial plasma. Hypoxanthine is positively correlated with pH, lactic acid, and alkali shortage. It is also directly correlated with survival time and elevated plasma hypoxanthine. The rate of hypoxanthine increase was inversely connected with survival time (r=-0.62). At 125 pM/L of hypoxanthine, every animal perished. Consequently, when compared to alkali deficit, an increase in hypoxanthine indicates the prognosis of acute hypoxia [1].
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| References |
[1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.
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| Additional Infomation |
Hypoxanthine is a purine nucleobase that consists of purine bearing an oxo substituent at position 6. It has a role as a fundamental metabolite. It is an oxopurine, a purine nucleobase and a nucleobase analogue. It is functionally related to an adenine.
Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. Hypoxanthine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Hypoxanthine is a purine-based organic compound in human muscle tissues, Hypoxanthine is formed during purine catabolism as a product of xanthine oxidase action on xanthine, and occasionally is found as a constituent of nucleic acids. The potent anti-inflammatory and cytoprotective effects of purines may be mediated by cell surface adenosine receptors. Hypoxanthine protects against oxidant-induced cell injury by inhibiting activation of nuclear poly(ADP-ribose) polymerase (PARP). (NCI04) Hypoxanthine is a metabolite found in or produced by Saccharomyces cerevisiae. A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. |
| Molecular Formula |
C5H4N4O
|
|---|---|
| Molecular Weight |
136.11
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| Exact Mass |
136.038
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| CAS # |
68-94-0
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| PubChem CID |
135398638
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| Appearance |
Off-white to pink solid powder
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| Density |
1.7±0.1 g/cm3
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| Boiling Point |
551.0±30.0 °C at 760 mmHg
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| Melting Point |
>300 °C(lit.)
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| Flash Point |
287.0±24.6 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
|
| Index of Refraction |
1.816
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| LogP |
-0.91
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
|
| Complexity |
190
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1C2=C(N=C([H])N1[H])N=C([H])N2[H]
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| InChi Key |
FDGQSTZJBFJUBT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
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| Chemical Name |
1,7-dihydropurin-6-one
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| Synonyms |
Hypoxanthine; 6-Hydroxypurine; 1,7-Dihydro-6H-purin-6-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~73.47 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (183.67 mM) in 0.5% CMC-Na/saline water (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3470 mL | 36.7350 mL | 73.4700 mL | |
| 5 mM | 1.4694 mL | 7.3470 mL | 14.6940 mL | |
| 10 mM | 0.7347 mL | 3.6735 mL | 7.3470 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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