My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    (-)-Huperzine A (HupA)
    (-)-Huperzine A (HupA)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1082
    CAS #: 102518-79-6Purity ≥98%

    Description: (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, it exhibits 200-fold more selectivity for G4 AChE over G1 AChE. It is an active Lycopodium alkaloid isolated from traditional Chinese herb. It also acts as an NMDA receptor antagonist. (-)-Huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration-particularly Alzheimer's disease. Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function.

    References: Eur J Pharmacol. 2002 Nov 29;455(2-3):101-7; Trends Pharmacol Sci. 2006 Dec;27(12):619-25.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Citation of InvivoChem venetoclax and S63845
    • Citation of InvivoChem KD025 (SLx-2119)
    • Citation of InvivoChem Tubastatin A HCl
    • Citation of InvivoChem Paclitaxel
    • Citation of InvivoChem Colchicine
    • Citation of InvivoChem CA-170
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)242.32
    FormulaC15H18N2O 
    CAS No.102518-79-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:<1 mg/mL
    Water: <1 mg/mL
    Ethanol:<1 mg/mL
    Solubility (In vivo)30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
    SynonymsHup A; Huperzine A; Selagine; (-)-huperzine A; (-)-Selagine.


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: (-)-Huperzine A is a novel alkaloid isolated from the Chinese herb Huperzia serrata. (-)-Huperzine A preferentially inhibits tetrameric AChE (G4 form). (-)-Huperzine A is more potent than tacrine, physostigmine, galanthamine, and rivastigmine with respect to inhibition of AChE activity, whereas HupA is the least potent BuChE inhibitor among the inhibitors. (-)-Huperzine A possesses the ability to protect cells against hydrogen peroxide, β-amyloid protein, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism.

    In Vivo(-)-Huperzine A can ameliorate the learning and memory deficiency in animal models and AD patients. Its potentially beneficial actions include modification of β-amyloid peptide processing, reduction of oxidative stress, neuronal protection against apoptosis, and regulation of the expression and secretion of nerve growth factor (NGF) and NGF signaling. (-)-Huperzine A significantly inhibits AChE activity in the cortex, hippocampus, striatum, medial septum, medulla oblongata, cerebellum, and hypothalamus of rats that are killed 30 min following the administration of (-)-Huperzine A at several dose levels compared with the saline control.
    Animal modelMale Sprague-Dawley rats
    Formulation & DosageDissolved in saline; 0.1mg/kg; oral gavage
    References

    Eur J Pharmacol. 2002 Nov 29;455(2-3):101-7; Trends Pharmacol Sci. 2006 Dec;27(12):619-25; Acta Pharmacol Sin. 2006 Jan;27(1):1-26.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    (-)-Huperzine A (HupA)

    Effects of the co-administration of huperzine A (0.2, 0.3 and 0.4 mg/kg) and morphine on locomotor activity in the development phase of behavioral sensitization. Exp Ther Med. 2017 Apr; 13(4): 1584–1591.
     

    (-)-Huperzine A (HupA)

    Examination of the state-dependency hypothesis. Exp Ther Med. 2017 Apr; 13(4): 1584–1591.
     
    An external file that holds a picture, illustration, etc.
Object name is etm-13-04-1584-g05.jpg
    Effects of huperzine A on the expression of morphine sensitization in the Sal+Mor group. Exp Ther Med. 2017 Apr; 13(4): 1584–1591.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Email: sales@invivochem.com
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved