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    HUHS015
    HUHS015

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2911
    CAS #: 1453097-13-6Purity ≥98%

    Description: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. 

    References:  2014 Feb 15;24(4):1071-4.


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    Molecular Weight (MW) 318.37 
    Formula C19H18N4O                 
    CAS No. 1453097-13-6                 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:  ≥ 34 mg/mL
    Water: <1 mg/mL
    Ethanol: 
    SMILES Code OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3
    Synonyms HUHS015; HUHS 015; HUHS-015


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    In Vitro

    In vitro activity: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. 


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    Cell Assay: 

    In VivoHUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. 
    Animal modelMouse xenograft model
    Formulation & Dosage
    References  2014 Feb 15;24(4):1071-4.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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