| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Targets |
Homodihydrocapsaicin I does not have a well-defined molecular target. As a capsaicinoid, it may interact with the transient receptor potential vanilloid 1 (TRPV1) channel, similar to capsaicin, although this has not been specifically confirmed. It exhibits phytotoxic effects on plants, suggesting it may interact with plant cellular targets involved in growth and development. Its biological activities are likely mediated through its phenolic structure, which can interact with various cellular components.
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| ln Vitro |
Elevated dihydrocapsaicin I can limit lettuce seedlings' root length and have a phytotoxic effect on their growth [1].
Homodihydrocapsaicin I exhibits phytotoxic effects on the seedling growth of lettuce (Lactuca sativa), reducing the radical length of seedlings. This demonstrates its biological activity as a plant growth inhibitor. Its activity as a capsaicinoid suggests it may also exhibit other biological effects, such as TRPV1 channel modulation, although specific data on its in vitro activity is limited. |
| ln Vivo |
Homodihydrocapsaicin I is a naturally occurring compound found in chili peppers. Its in vivo effects are primarily related to its role as a plant metabolite. It may contribute to the defense mechanisms of the plant against herbivores and pathogens. However, specific in vivo pharmacological data in animal models is not available in the provided sources.
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| Enzyme Assay |
Homodihydrocapsaicin I does not have a conventional enzyme/receptor binding assay. Its activity is assessed in plant-based bioassays, where its effects on seedling growth and development are measured. Lettuce seeds are germinated in the presence of the compound, and the inhibition of radical length is measured to assess its phytotoxic activity.
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| Cell Assay |
In vitro cellular experiments for Homodihydrocapsaicin I are limited. Plant-based assays are the primary method for studying its activity. Lettuce seedlings are treated with the compound, and the effects on growth parameters such as radical length and germination rate are assessed. Its effects on other plant species or cell cultures have not been extensively documented.
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| Animal Protocol |
In vivo animal experiments for Homodihydrocapsaicin I are not documented in the available literature. As a naturally occurring compound in chili peppers, it may be consumed as part of the diet, but specific pharmacological studies in animal models have not been reported. Its primary research applications are in plant biology.
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| ADME/Pharmacokinetics |
Homodihydrocapsaicin I has a molecular weight of 321.45 g/mol and a molecular formula of C19H31NO3. It is a member of the capsaicinoid family. The compound is typically stored at 2-8°C and is supplied as a powder with a purity of ≥98%. It is soluble in organic solvents and is used as a research reagent.
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| Toxicity/Toxicokinetics |
Homodihydrocapsaicin I is a research compound that is not intended for human use. As a naturally occurring compound in chili peppers, it is generally considered to have low toxicity. However, as with all research chemicals, standard safety precautions should be followed when handling. Its safety profile for therapeutic applications would need to be established.
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| References | |
| Additional Infomation |
Homodihydrocapsaicin is a member of the methoxybenzene class and also a member of the phenol class. It has been reported in chili peppers, Phylica pubescens, and Capsicum annuum var. ...
Homodihydrocapsaicin I is a naturally occurring capsaicinoid found in Capsicum annuum fruits. It exhibits phytotoxic effects on lettuce seedling growth. The compound is a member of the methoxybenzenes and phenols chemical classes. It is available from various chemical suppliers for research purposes and is used in studies of plant biology and natural product chemistry. |
| Molecular Formula |
C19H31NO3
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|---|---|
| Molecular Weight |
321.45434
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| Exact Mass |
321.23
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| CAS # |
20279-06-5
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| PubChem CID |
3084336
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.017g/cm3
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| Boiling Point |
508ºC at 760 mmHg
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| Melting Point |
70 - 71 °C
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| Flash Point |
261ºC
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| Vapour Pressure |
6.08E-11mmHg at 25°C
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| Index of Refraction |
1.508
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| LogP |
5.244
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
23
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| Complexity |
320
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
AKDLSISGGARWFP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H31NO3/c1-15(2)9-7-5-4-6-8-10-19(22)20-14-16-11-12-17(21)18(13-16)23-3/h11-13,15,21H,4-10,14H2,1-3H3,(H,20,22)
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| Chemical Name |
N-[(4-hydroxy-3-methoxyphenyl)methyl]-9-methyldecanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~311.09 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1109 mL | 15.5545 mL | 31.1090 mL | |
| 5 mM | 0.6222 mL | 3.1109 mL | 6.2218 mL | |
| 10 mM | 0.3111 mL | 1.5555 mL | 3.1109 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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