| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g | |||
| Other Sizes |
Purity: ≥98%
Heptaminol HCl (RP-2831), the hydrochloride of heptaminol which is an amino alcohol, is a novel and potent vasoconstrictor used in the treatment of low blood pressure, particularly orthostatic hypotension. It is also used as a myocardial stimulant, vasodilator, and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.
| ln Vivo |
Topical pretreatment with heptaminol (2.5 nmol per ear) significantly attenuated TPA-induced epidermal hyperplasia, skin edema, and fibrosis in Balb/c mouse ear skin. This protective effect was NO-dependent, as it was abolished by co-treatment with the NO scavenger cPTIO. [2]
Heptaminol pretreatment did not inhibit TPA-induced infiltration of CD45+ leukocytes or γδ T cells into the ear skin. [2] Heptaminol pretreatment attenuated TPA-induced depletion of tissue-marginating NK cells in mouse ear skin, and this protective effect was abolished by co-treatment with the NOS inhibitor L-NAME, indicating NO dependence. [2] |
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| Animal Protocol |
Female Balb/c mice (5 weeks old) were used. Drugs were dissolved in 12 μL of vehicle (acetone for most compounds; heptaminol was dissolved in 50% water/acetone). Pretreatment with heptaminol (2.5 nmol per ear) was applied topically to the ear skin 30 minutes before topical application of TPA (0.4 nmol per ear in acetone). Ear thickness and histological changes were assessed 24 hours after TPA treatment. For flow cytometry analysis of immune cells, ears were collected and processed for cell isolation and staining. [2]
In the NK cell depletion study, mice were pretreated topically with heptaminol (2.5 nmol per ear) with or without L-NAME (a NOS inhibitor) 30 minutes before TPA application. Ears were collected 24 hours later for flow cytometric analysis of NK cells. [2] |
| References | |
| Additional Infomation |
Heptanol is an amino alcohol that has been used as a myocardial stimulant and vasodilator, and to relieve bronchospasm. Its most common therapeutic use is for the treatment of orthostatic hypotension. The mechanism of action of heptanol is not fully understood, but studies have shown that it may affect the release of catecholamines or calcium metabolism. Heptanol is described as a vasodilator and a general antagonist of catecholamine release and uptake. It also increases intracellular free calcium levels. [2] Studies have shown that the antiproliferative and anti-inflammatory effects of heptanol are achieved by stimulating the production of endogenous nitric oxide (NO), possibly from constitutive nitric oxide synthases such as NOS3. [2] Heptanol did not block TPA-induced vascular leakage or the infiltration of autofluorescent leukocytes (e.g., neutrophils/macrophages), as observed by autofluorescence two-photon microscopy. [2] The protective effect of heptanol against TPA-induced NK cell exhaustion is NO-dependent. [2]
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| Molecular Formula |
C8H20CLNO
|
|---|---|
| Molecular Weight |
181.70300
|
| Exact Mass |
181.123
|
| CAS # |
543-15-7
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| Related CAS # |
372-66-7;543-15-7 (HCl);
|
| PubChem CID |
10969
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| Appearance |
White to off-white solid powder
|
| Density |
0.895g/cm3
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| Boiling Point |
250.1ºC at 760mmHg
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| Melting Point |
165-167 °C(lit.)
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| Flash Point |
105.1ºC
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| LogP |
2.777
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
11
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| Complexity |
91.3
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
JZNBMCOSOXIZJB-UHFFFAOYSA-N
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| InChi Code |
1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H
|
| Chemical Name |
2-Heptanol, 6-amino-2-methyl-, hydrochloride
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| Synonyms |
RP-2831 hydrochloride; RP 2831 hydrochloride; RP2831 hydrochloride; Arcor tropfen, Cardiosintol, Corasor, Coreptil, Cortensor, Delmiton, EA-85, Heptaminol HCl, Heptaminol hydrochloride, Respirin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~550.36 mM)
H2O : ≥ 100 mg/mL (~550.36 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (550.36 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5036 mL | 27.5179 mL | 55.0358 mL | |
| 5 mM | 1.1007 mL | 5.5036 mL | 11.0072 mL | |
| 10 mM | 0.5504 mL | 2.7518 mL | 5.5036 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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