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    Halobetasol Propionate
    Halobetasol Propionate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0841
    CAS #: 66852-54-8Purity ≥98%

    Description:  Halobetasol Propionate (also known as halobetasol, BMY-30056, and CGP-14458) is a potent and synthetic corticosteroid acting as an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. 

    References: Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):186-7; Am J Clin Dermatol. 2005;6(5):311-6.

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    Molecular Weight (MW)484.96
    FormulaC25H31ClF2O5
    CAS No.66852-54-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 97 mg/mL (200.0 mM)
    Water: <1 mg/mL
    Ethanol: 38 mg/mL (78.4 mM)
    SMILESC[[email protected]@]12[[email protected]](C(CCl)=O)(OC(CC)=O)[[email protected]@H](C)C[[email protected]@]1([H])[[email protected]]3([H])C[[email protected]](F)C4=CC(C=C[[email protected]]4(C)[[email protected]@]3(F)[[email protected]@H](O)C2)=O
    SynonymsHalobetasol Propionate; BMY30056, CGP14458; BMY 30056, CGP 14458; BMY-30056; CGP-14458; Ulobetasol propionate


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    In Vitro

    In vitro activity: Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

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    References

    Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):186-7; Am J Clin Dermatol. 2005;6(5):311-6.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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