| Size | Price | Stock | Qty |
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| 2g |
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| 5g |
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| Other Size |
| ln Vitro |
The efficient tyrosine hydroxylase inhibitor is H-Tyr(3-I)-OH (3-iodo-L-tyrosine). The enzyme activity is 100% inhibited by 3-iodo-L-tyrosine at a concentration of 100μM and 60–70% inhibited at a concentration of 10μM[1].
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| References | |
| Additional Infomation |
3-Iodotyrosine is a monoiodotyrosine, specifically an L-tyrosine with an iodine substituent at the C-3 position of its benzyl group. It is a human metabolite, an inhibitor of EC 1.14.16.2 (tyrosine 3-monooxygenase), and a murine metabolite. It is an L-tyrosine derivative, a non-protein L-α-amino acid, and also a monoiodotyrosine. It is a zwitterion tautomer of 3-iodotyrosine. Iodotyrosine is present in or produced by Escherichia coli (K12 strain, MG1655 strain). Monoiodotyrosine has been reported to exist in humans, and relevant data are available. 3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones and is a derivative of tyrosine, with its benzyl group at the C-3 position iodinated by thyroid peroxidase. 3-Iodotyrosine (monoiodotyrosine) can be further iodinated by thyroid peroxidase to form diiodo and triiodoform forms. Monoiodotyrosine can combine with diiodotyrosine to form triiodothyronine (T3), and two diiodotyrosines can combine to form thyroxine (T4).
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| Molecular Formula |
C9H10INO3
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|---|---|
| Molecular Weight |
307.0851
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| Exact Mass |
306.97
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| CAS # |
70-78-0
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| PubChem CID |
439744
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| Appearance |
White to off-white solid powder
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| Density |
1.9±0.1 g/cm3
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| Boiling Point |
391.0±42.0 °C at 760 mmHg
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| Melting Point |
210 °C (dec.)(lit.)
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| Flash Point |
190.3±27.9 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.689
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| LogP |
1.54
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
14
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| Complexity |
212
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)O
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| InChi Key |
UQTZMGFTRHFAAM-ZETCQYMHSA-N
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| InChi Code |
InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
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| Chemical Name |
(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~5 mg/mL (~16.28 mM)
DMSO : ~1 mg/mL (~3.26 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 3.33 mg/mL (10.84 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2564 mL | 16.2819 mL | 32.5637 mL | |
| 5 mM | 0.6513 mL | 3.2564 mL | 6.5127 mL | |
| 10 mM | 0.3256 mL | 1.6282 mL | 3.2564 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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