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| Other Sizes |
| Targets |
H-Trp-NH2.HCl is classified as a tryptophan analogue and amino acid amide. It does not have a specific biological receptor target. Its primary application is as a building block in peptide synthesis and organic chemistry. The amide group at the C-terminus provides a different functionality compared to the free acid, enabling the synthesis of peptide amides and other derivatives. Tryptophan is important for protein structure and function.
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| ln Vitro |
In vitro activity for H-Trp-NH2.HCl is primarily as a synthetic building block. Amino acid derivatives have been commercially studied as ergogenic supplements, affecting the release of anabolic hormones, fuel availability, mental performance, and prevention of muscular damage. H-Trp-NH2.HCl itself is not directly biologically active; its utility is in preparing tryptophan amide-containing compounds for subsequent evaluation.
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| ln Vivo |
In vivo activity data for H-Trp-NH2.HCl as a standalone compound is not applicable. It is a tryptophan amide derivative used as a research building block and is not intended for direct in vivo administration. Compounds synthesized using this building block may be evaluated in animal models for various biological activities.
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| Enzyme Assay |
In vitro synthetic protocols for H-Trp-NH2.HCl involve its use as a building block in peptide synthesis. The compound can be coupled to other amino acids or molecules using standard peptide coupling chemistry. The amide group provides a different reactivity profile compared to the free acid. Purity is typically high.
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| Cell Assay |
Cell-based protocols are not directly applicable to H-Trp-NH2.HCl as it is a synthetic building block. Compounds synthesized using this reagent can be tested in cell culture. Compounds are dissolved in DMSO or appropriate buffers and added to cells at concentrations of 0.1-100 µM for 24-72 hours.
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| Animal Protocol |
Animal studies with H-Trp-NH2.HCl are not conducted directly. The compound may be used as a synthetic intermediate to prepare compounds for pharmaceutical research. Standard synthetic chemistry protocols are used to convert this intermediate into target molecules for potential in vivo evaluation.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for H-Trp-NH2.HCl as a standalone compound is not applicable. The compound has a molecular weight of 239.70 g/mol and formula C11H14ClN3O. It has a CAS number of 5022-65-1. Storage is recommended in a cool, dry place.
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| Toxicity/Toxicokinetics |
Limited toxicological data is available for H-Trp-NH2.HCl. The compound is for research use only and is not intended for human therapeutic use. Standard safety precautions for handling laboratory chemicals should be observed. No specific toxicity studies have been reported.
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| Additional Infomation |
H-Trp-NH2.HCl (CAS#: 5022-65-1) is also known as L-tryptophanamide hydrochloride and (S)-2,5-diamino-5-oxopentanoic acid. It is a tryptophan analogue and amino acid amide used in peptide synthesis. It has no approved therapeutic indications.
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| Molecular Formula |
C11H14CLN3O
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|---|---|
| Molecular Weight |
239.7014
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| Exact Mass |
293.101
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| CAS # |
5022-65-1
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| PubChem CID |
6452180
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| Appearance |
White to off-white powder
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| Boiling Point |
498.7ºC at 760mmHg
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| Melting Point |
250ºC
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| Flash Point |
255.4ºC
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| Index of Refraction |
25 ° (C=1, H2O)
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| Source |
Endogenously produced metabolite
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| LogP |
1.079
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
16
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| Complexity |
244
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| Defined Atom Stereocenter Count |
1
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| SMILES |
Cl[H].O=C([C@]([H])(C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)N([H])[H])N([H])[H]
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| InChi Key |
WOBDANBSEWOYKN-FVGYRXGTSA-N
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| InChi Code |
InChI=1S/C11H13N3O.ClH/c12-9(11(13)15)5-7-6-14-10-4-2-1-3-8(7)10;/h1-4,6,9,14H,5,12H2,(H2,13,15);1H/t9-;/m0./s1
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| Chemical Name |
(2S)-2-amino-3-(1H-indol-3-yl)propanamide;hydrochloride
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| Synonyms |
H-Trp-NH2.HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~417.19 mM)
H2O : ~100 mg/mL (~417.19 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.43 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1719 mL | 20.8594 mL | 41.7188 mL | |
| 5 mM | 0.8344 mL | 4.1719 mL | 8.3438 mL | |
| 10 mM | 0.4172 mL | 2.0859 mL | 4.1719 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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